{"id":"W2093266648","doi":"10.1074/jbc.m113.461715","title":"Regulation of the Human Ether-a-go-go-related Gene (hERG) Channel by Rab4 Protein through Neural Precursor Cell-expressed Developmentally Down-regulated Protein 4-2 (Nedd4-2)","year":2013,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"hERG; NEDD4; Potassium channel; Ubiquitin ligase; Cell biology; Ubiquitin; Cardiac action potential; Biology; Chemistry; Repolarization; Biochemistry; Endocrinology; Gene; Electrophysiology; Neuroscience","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000225394,0.0002972335,0.0002240486,0.000165679,0.000146192,0.0003540942,0.0002307154,0.0002659593,0.0006832422],"category_scores_gemma":[0.0001542029,0.0001608173,0.0003888339,0.00009708578,0.0002562758,0.0002318444,0.0002197018,0.0003726906,0.0002533858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005979038,"about_ca_system_score_gemma":0.0002562018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007166666,"about_ca_topic_score_gemma":0.0008052487,"domain_scores_codex":[0.9998243,0.00004404089,0.00002399972,0.00003970311,0.00003382263,0.00003409626],"domain_scores_gemma":[0.9999408,0.00001106062,0.00002036728,0.000008241064,0.000009922596,0.000009671226],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001264967,0.00003485633,0.0002197685,0.00003108834,0.000007636449,0.0000721429,0.00001254179,0.0001260581,0.9981857,0.0002250087,0.00004407586,0.0009146056],"study_design_scores_gemma":[0.00005357326,0.0001984364,0.004111629,0.000004160363,0.00001937072,0.0002688926,0.00003027132,0.003598924,0.988097,0.00006986717,0.003540755,0.00000718118],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948873,0.001693132,0.002077673,0.0001221843,0.0000361847,0.00003035363,0.0001856996,0.00006763583,0.0008999563],"genre_scores_gemma":[0.9926576,0.0008886794,0.003468265,0.0000731023,0.000006087244,0.00005350508,0.000372733,0.00002086054,0.00245917],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007166666,"threshold_uncertainty_score":0.004338145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01160485672829266,"score_gpt":0.2118926208684303,"score_spread":0.2002877641401377,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}