{"id":"W2093318209","doi":"10.1016/j.devcel.2009.10.023","title":"CBP Histone Acetyltransferase Activity Regulates Embryonic Neural Differentiation in the Normal and Rubinstein-Taybi Syndrome Brain","year":2010,"lang":"en","type":"article","venue":"Developmental Cell","topic":"Autism Spectrum Disorder Research","field":"Neuroscience","cited_by":186,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research; Howard Hughes Medical Institute","keywords":"Haploinsufficiency; Biology; CREB-binding protein; Histone acetyltransferase; Histone; Acetylation; Histone methyltransferase; Acetyltransferase; Epigenetics; Histone H4; Cell biology; Genetics; Gene; CREB; Phenotype; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003085266,0.0002054379,0.0001658669,0.00015725,0.000295254,0.0001171982,0.0004009728,0.00009078132,0.0001774926],"category_scores_gemma":[0.00006556706,0.000167162,0.00003805829,0.0003798419,0.0002154336,0.0003840334,0.00014265,0.0006610757,0.00006213398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008489141,"about_ca_system_score_gemma":0.00008260353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001100348,"about_ca_topic_score_gemma":0.0006620733,"domain_scores_codex":[0.9981995,0.000210097,0.0001847193,0.0004673225,0.0004537456,0.0004846367],"domain_scores_gemma":[0.9993937,0.0002505695,0.00004820802,0.0002142957,0.000004174463,0.00008906638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005015156,0.0002118753,0.006381712,0.00003303184,0.000001766926,0.00008764769,0.001600834,0.000002248535,0.9892658,0.0005605732,0.00004826106,0.001756071],"study_design_scores_gemma":[0.0008904839,0.00007162603,0.508213,0.000005998273,0.000003079906,0.0002975896,0.00009106876,0.0007565957,0.4889833,0.0002634912,0.0001927127,0.0002310352],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933546,0.00002277361,0.00001725161,0.004433696,0.0001544325,0.000478564,0.000009869556,0.00004682146,0.001481984],"genre_scores_gemma":[0.9987254,0.00001657775,0.00006657156,0.0003368801,0.000009999525,0.00003957408,0.000009118309,0.00002304656,0.0007728421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5018314,"threshold_uncertainty_score":0.6816669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01399016452440231,"score_gpt":0.2522485162032506,"score_spread":0.2382583516788483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}