{"id":"W2093333141","doi":"10.1038/bjp.2008.353","title":"Low doses of α<sub>2</sub>‐adrenoceptor antagonists augment spinal morphine analgesia and inhibit development of acute and chronic tolerance","year":2008,"lang":"en","type":"article","venue":"British Journal of Pharmacology","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Canada Research Chairs; Canadian Institutes of Health Research; Ontario Innovation Trust","keywords":"Augment; Morphine; Medicine; Pharmacology; Anesthesia; Drug tolerance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009237752,0.0003401552,0.000371771,0.0001285806,0.00009024811,0.0002403487,0.0002252423,0.000257155,0.003048481],"category_scores_gemma":[0.0002048113,0.0001410082,0.000175291,0.00008195941,0.000216668,0.0002131742,0.0001053408,0.001091288,0.0005227238],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001790355,"about_ca_system_score_gemma":0.0001675078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003347356,"about_ca_topic_score_gemma":0.00114403,"domain_scores_codex":[0.9999064,0.00001578004,0.00001062005,0.0000104323,0.00002280501,0.00003396501],"domain_scores_gemma":[0.9998292,0.00003881887,0.00005553382,0.00001403768,0.00001859084,0.00004379759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007616309,0.0001557101,0.0003248505,0.00005195606,0.00001142896,0.00002493678,0.00001096001,0.00003276893,0.9964169,0.00003152698,0.00003898665,0.002138324],"study_design_scores_gemma":[0.0002970611,0.01770401,0.02483552,0.00004058991,0.00009956462,0.0006029945,0.00008253945,0.0007791921,0.9531834,0.00005709603,0.002305346,0.00001275019],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962077,0.001956969,0.0006267724,0.00006995573,0.00002771565,0.00002686642,0.0001231124,0.00004207914,0.0009189348],"genre_scores_gemma":[0.9953454,0.001317607,0.001390357,0.0001232059,0.00004812826,0.0000455923,0.0002436177,0.00000884969,0.001477075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003048481,"threshold_uncertainty_score":0.01019818,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01180013852259261,"score_gpt":0.2734233929705702,"score_spread":0.2616232544479776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}