{"id":"W2093348278","doi":"10.1021/bi7023089","title":"Cytosolic Region of TM6 in P-Glycoprotein: Topographical Analysis and Functional Perturbation by Site Directed Labeling","year":2008,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Cancer Research UK","keywords":"Cytosol; Chemistry; Biochemistry; Efflux; Vanadate; Cysteine; ATP-binding cassette transporter; Conformational change; ATP hydrolysis; Gene isoform; Chromosomal translocation; Transporter; Biophysics; ATPase; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005320418,0.00008815153,0.0002158041,0.0001082118,0.00003568548,0.000002231395,0.00002044962,0.0001297734,0.00003023969],"category_scores_gemma":[0.00002179035,0.00007850272,0.00008620385,0.0005924139,0.00007673338,0.00001942236,0.000005671464,0.0001019805,4.019377e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000019594,"about_ca_system_score_gemma":0.00003297398,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004110673,"about_ca_topic_score_gemma":0.000009878499,"domain_scores_codex":[0.9993114,0.000007541371,0.0001976379,0.0002038226,0.0001745005,0.0001051369],"domain_scores_gemma":[0.9996803,0.00001377486,0.00005692927,0.0001277171,0.0000576171,0.00006364406],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000205776,0.0001109351,0.1410199,0.0001056612,0.00009744983,0.00003974179,0.00008291041,0.000001935375,0.8580165,0.000008695562,0.0001554117,0.0001551325],"study_design_scores_gemma":[0.001321637,0.00004547603,0.1917257,0.0001109778,0.0002802702,0.00006349542,0.00005736979,0.0004912072,0.8055604,0.00003898046,0.0001523508,0.0001520854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976148,0.001181525,0.0006126641,0.0002125542,0.00001483488,0.00007462718,0.000008684013,0.00003224177,0.0002480635],"genre_scores_gemma":[0.9976152,0.0002608921,0.0004595376,0.00003913727,0.00003987703,0.000008431399,0.0002397468,0.000006772704,0.001330458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05245607,"threshold_uncertainty_score":0.3201248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009372463740714442,"score_gpt":0.2043923441129452,"score_spread":0.1950198803722307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}