{"id":"W2093356656","doi":"10.1111/ejn.12235","title":"Amyloid‐β protein (Aβ) Glu11 is the major β‐secretase site of β‐site amyloid‐β precursor protein‐cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis","year":2013,"lang":"en","type":"article","venue":"European Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Amyloid precursor protein; Amyloid precursor protein secretase; Cleavage (geology); Alpha secretase; Chemistry; Senile plaques; P3 peptide; BACE1-AS; Cell biology; Biochemistry; Alzheimer's disease; Molecular biology; Genetically modified mouse; Biology; Transgene; Gene; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001875593,0.0003766087,0.0004968542,0.0002685357,0.0005587483,0.0003503415,0.0006704053,0.00003401482,0.00004220085],"category_scores_gemma":[0.001234199,0.0002127209,0.0002280419,0.0009357628,0.0004410339,0.0004627253,0.0004836592,0.0004916535,0.0002314247],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004334169,"about_ca_system_score_gemma":0.0001777245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006201064,"about_ca_topic_score_gemma":0.000005951341,"domain_scores_codex":[0.9956602,0.0009946022,0.0008328345,0.0005701371,0.001165146,0.0007770807],"domain_scores_gemma":[0.9970475,0.0002126327,0.0005709461,0.0006983423,0.000522593,0.0009479777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0006780411,0.0003024413,0.009785689,0.00005785217,0.0004508258,0.0008218923,0.00181745,0.00001251534,0.9774441,0.00002270712,0.001485107,0.007121401],"study_design_scores_gemma":[0.003013738,0.004400692,0.7130388,0.001235452,0.001016628,0.0004409871,0.0004926908,0.0003783839,0.2712261,0.00003898633,0.004242431,0.0004751432],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.984592,0.003954879,0.0002614119,0.007818223,0.0001034209,0.002883093,0.0001134292,0.00002631894,0.0002471935],"genre_scores_gemma":[0.9959495,0.00004604668,0.0008355931,0.002717506,0.0001735392,0.00004325369,0.000002482484,0.00006735927,0.0001646875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.706218,"threshold_uncertainty_score":0.8674507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02947542549793521,"score_gpt":0.2762910900989139,"score_spread":0.2468156646009787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}