{"id":"W2093356656","doi":"10.1111/ejn.12235","title":"Amyloid‐β protein (Aβ) Glu11 is the major β‐secretase site of β‐site amyloid‐β precursor protein‐cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis","year":2013,"lang":"en","type":"article","venue":"European Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Amyloid precursor protein; Amyloid precursor protein secretase; Cleavage (geology); Alpha secretase; Chemistry; Senile plaques; P3 peptide; BACE1-AS; Cell biology; Biochemistry; Alzheimer's disease; Molecular biology; Genetically modified mouse; Biology; Transgene; Gene; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001020261,0.0004978725,0.0002591234,0.000243587,0.0003046566,0.0004759945,0.0001489783,0.0003068887,0.0007228412],"category_scores_gemma":[0.0001301867,0.0001552126,0.0003045422,0.0002214994,0.0001846988,0.0002707792,0.000245974,0.0003869369,0.000542117],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002418862,"about_ca_system_score_gemma":0.0001979389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006065773,"about_ca_topic_score_gemma":0.0004136685,"domain_scores_codex":[0.9999098,0.0000101604,0.00001317117,0.00002879912,0.00002563942,0.0000125225],"domain_scores_gemma":[0.9998982,0.000009790785,0.00004524899,0.000008088247,0.00001852194,0.00002019251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008018131,0.00003849113,0.001873613,0.00005881152,0.00001119673,0.0003363311,0.00002776778,0.00008586136,0.9925048,0.0001952453,0.0001045841,0.00468309],"study_design_scores_gemma":[0.0000201808,0.0004735031,0.0351352,0.00002867414,0.00006849236,0.004248195,0.000127411,0.0008893608,0.9460325,0.0002929144,0.01266851,0.00001511772],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905952,0.003521227,0.004043935,0.00007262652,0.0000573465,0.00003632731,0.0003231139,0.0000831052,0.001267077],"genre_scores_gemma":[0.987855,0.004653053,0.00339227,0.00005719064,0.00002795958,0.00002648566,0.0007478861,0.00001118122,0.003229006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007228412,"threshold_uncertainty_score":0.00241822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02947542549793521,"score_gpt":0.2762910900989139,"score_spread":0.2468156646009787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}