{"id":"W2093369894","doi":"10.1136/bmj.c4777","title":"Is it time to revisit orphan drug policies?","year":2010,"lang":"en","type":"letter","venue":"BMJ","topic":"Health Systems, Economic Evaluations, Quality of Life","field":"Economics, Econometrics and Finance","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Orphan drug; Drug; Medicine; Computer science; Data science; Pharmacology; Bioinformatics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.016132,0.0007445954,0.001512298,0.001143475,0.004348505,0.006177985,0.003358691,0.09822579,0.01370721],"category_scores_gemma":[0.07613119,0.0008586109,0.00208274,0.001169861,0.008001862,0.01327164,0.00395171,0.07164824,0.009035043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.008890049,"about_ca_system_score_gemma":0.01355587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009481122,"about_ca_topic_score_gemma":0.01413404,"domain_scores_codex":[0.9891115,0.003639431,0.001563557,0.00107281,0.003180687,0.001432093],"domain_scores_gemma":[0.944203,0.03739069,0.002447942,0.001948568,0.006869798,0.00714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005063685,0.00006709764,0.000533246,0.0001076976,0.00001487039,0.0007683079,0.0002288075,0.00009167434,0.0001866052,0.01535509,0.9622392,0.02035668],"study_design_scores_gemma":[0.0001062539,0.00004863099,0.0007877019,0.0006341195,0.00001468391,0.0007714856,0.0006119307,0.0003612041,0.0001447973,0.02645116,0.9699981,0.00007006436],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001061997,0.0005018596,0.00004611398,0.9963576,0.002376923,0.000002772071,0.00001205326,0.000007019224,0.0005893295],"genre_scores_gemma":[0.001082429,0.0005171694,0.0001970912,0.9910029,0.005977158,0.00001191337,0.00001155424,0.000009260919,0.001190521],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.09822579,"threshold_uncertainty_score":0.08531517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3086571856141224,"score_gpt":0.4514813306092,"score_spread":0.1428241449950776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}