{"id":"W2093386502","doi":"10.1126/science.1175602","title":"Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase","year":2009,"lang":"en","type":"article","venue":"Science","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":385,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences","keywords":"Lovastatin; Polyketide; Enzyme; Polyketide synthase; Biochemistry; Cofactor; Function (biology); Chemistry; ATP synthase; Stereochemistry; Computational biology; Biology; Combinatorial chemistry; Biosynthesis; Genetics; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003197738,0.0005655527,0.0003769601,0.0001746414,0.0002001869,0.0005073246,0.0004940548,0.0003300442,0.0007441974],"category_scores_gemma":[0.0002598996,0.0002013179,0.0002313785,0.0002991839,0.0003040516,0.0002794991,0.0004988969,0.0007020142,0.0005854499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004327146,"about_ca_system_score_gemma":0.0003784959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001164421,"about_ca_topic_score_gemma":0.0008960548,"domain_scores_codex":[0.9997095,0.00005011011,0.00004524426,0.00006107127,0.00009078841,0.00004313015],"domain_scores_gemma":[0.999791,0.00002905533,0.0000468287,0.00006001385,0.00002342921,0.00004963811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001339178,0.00004469071,0.0001503575,0.00004105539,0.00001198931,0.00004550675,0.00003074194,0.0002916669,0.9972423,0.000440066,0.0000708921,0.001496835],"study_design_scores_gemma":[0.00002435598,0.0001320169,0.0006209678,0.000006224963,0.00001449307,0.0001111945,0.0000191825,0.001251927,0.9916686,0.0001155134,0.006024923,0.00001058899],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9741169,0.0009908208,0.01970175,0.0001788957,0.0001163877,0.0001088091,0.002674853,0.0003932893,0.001718301],"genre_scores_gemma":[0.9773906,0.0006386072,0.01262027,0.00003597017,0.00001397653,0.00006520822,0.005872312,0.0001335957,0.00322959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001164421,"threshold_uncertainty_score":0.003139555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0236332920531524,"score_gpt":0.2796654121523001,"score_spread":0.2560321200991477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}