{"id":"W2093386502","doi":"10.1126/science.1175602","title":"Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase","year":2009,"lang":"en","type":"article","venue":"Science","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":385,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences","keywords":"Lovastatin; Polyketide; Enzyme; Polyketide synthase; Biochemistry; Cofactor; Function (biology); Chemistry; ATP synthase; Stereochemistry; Computational biology; Biology; Combinatorial chemistry; Biosynthesis; Genetics; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003688303,0.00005996864,0.0001345388,0.0001229881,0.0001173976,0.00001719398,0.00009720039,0.00001982431,0.00004615419],"category_scores_gemma":[0.0004838882,0.0000417786,0.00003050724,0.0005065181,0.0004971861,0.0001660887,0.00001542268,0.00007139359,0.0000117829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004499295,"about_ca_system_score_gemma":0.0001689527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000263393,"about_ca_topic_score_gemma":0.000001048384,"domain_scores_codex":[0.999276,0.00001239945,0.0001480636,0.0002325792,0.0001762663,0.0001547177],"domain_scores_gemma":[0.9995198,0.00001926161,0.00006360312,0.0001800764,0.0001474913,0.00006977577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003739895,0.00003165287,0.00003417672,0.000007972194,0.00000159211,0.000004305517,0.0001118878,0.000001366614,0.9755627,0.0007425111,0.000149421,0.023315],"study_design_scores_gemma":[0.0001446784,0.0001966318,0.005742356,0.0002178664,0.00001298315,0.00005902231,0.00002929379,0.0001066095,0.9915512,0.0001173338,0.001760075,0.00006195246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909675,0.0002441376,0.00005446998,0.005044362,0.0001436412,0.0001572292,0.00001227293,0.00002159244,0.003354774],"genre_scores_gemma":[0.9960481,0.00001726101,0.003299871,0.0003851083,0.00006473056,9.295627e-8,0.000001671217,0.000001236505,0.0001819647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02325304,"threshold_uncertainty_score":0.1831903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0236332920531524,"score_gpt":0.2796654121523001,"score_spread":0.2560321200991477,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}