{"id":"W2093390545","doi":"10.1111/j.1538-7836.2006.01953.x","title":"Tailored prophylaxis in severe hemophilia A: interim results from the first 5 years of the Canadian Hemophilia Primary Prophylaxis Study","year":2006,"lang":"en","type":"article","venue":"Journal of Thrombosis and Haemostasis","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":237,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University; Children's Hospital of Eastern Ontario; Hôpital de l'Enfant-Jésus; Health Sciences Centre; CancerCare Manitoba; BC Children's Hospital; Hamilton Health Sciences; Dalhousie University; University of Toronto; SickKids Foundation; Regional Municipality of Niagara; Hospital for Sick Children","funders":"","keywords":"Medicine; Clotting factor; Hemarthrosis; Cohort; Interim analysis; Confidence interval; Pediatrics; Surgery; Prophylactic treatment; Factor IX; Cohort study; Randomized controlled trial; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002812676,0.0007623563,0.001677732,0.0004667086,0.001492141,0.001264199,0.001291943,0.001143409,0.001726516],"category_scores_gemma":[0.00514718,0.000351048,0.001296331,0.002127224,0.0005324087,0.0005483553,0.0008015048,0.00107674,0.000179202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01171859,"about_ca_system_score_gemma":0.02213484,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9089451,"about_ca_topic_score_gemma":0.926181,"domain_scores_codex":[0.9978535,0.0004220849,0.00009904931,0.0002150386,0.0008098069,0.0006004102],"domain_scores_gemma":[0.99665,0.0003801238,0.0007215165,0.0002435582,0.0009493231,0.001055421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.04663166,0.002381815,0.8553314,0.0006597661,0.005171176,0.0001846283,0.0009217258,0.001778017,0.0007241667,0.0005570497,0.009992767,0.07566588],"study_design_scores_gemma":[0.00140301,0.001073347,0.9934711,0.00007449288,0.00161552,0.00003197354,0.0001530836,0.0002370741,0.00009108215,0.00007174932,0.001744632,0.00003286026],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.977062,0.009905133,0.0001612756,0.0008134301,0.00007326136,0.0002502154,0.008227157,0.0000186844,0.003488932],"genre_scores_gemma":[0.9888391,0.00358747,0.0003143309,0.0003884668,0.00004784577,0.0001055797,0.005487313,0.000005906561,0.001223877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09105492,"threshold_uncertainty_score":0.1831822,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04469508532536309,"score_gpt":0.2973268049179166,"score_spread":0.2526317195925535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}