{"id":"W2093415150","doi":"10.1006/mthe.2002.0723","title":"Ultrasound Increases Plasmid-Mediated Gene Transfer to Dystrophic Muscles without Collateral Damage","year":2002,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Muscle Physiology and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital; Concordia University; McGill University Health Centre","funders":"","keywords":"Transfection; Microbubbles; Ultrasound; Duchenne muscular dystrophy; Genetic enhancement; Muscular dystrophy; Plasmid; Sonoporation; DNA; Gene; Cell biology; Molecular biology; Biology; Chemistry; Medicine; Internal medicine; Biochemistry; Radiology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004070932,0.0005222248,0.0004366317,0.0005324592,0.0001173193,0.0002933555,0.0002184417,0.000461317,0.001659831],"category_scores_gemma":[0.0004299913,0.000211232,0.0002720763,0.0001911094,0.0004369577,0.0003575333,0.0004517557,0.0004954129,0.0002351851],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003226862,"about_ca_system_score_gemma":0.0002681728,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005127109,"about_ca_topic_score_gemma":0.0008570652,"domain_scores_codex":[0.9996173,0.00009795072,0.00003672213,0.00008300579,0.00009419289,0.00007080928],"domain_scores_gemma":[0.9995849,0.0001990133,0.00009518421,0.00002481542,0.00003229788,0.0000638022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004709467,0.00003767721,0.00005645919,0.0000335801,0.000002781877,0.00001952484,0.00002077336,0.00003003671,0.9988558,0.00003884971,0.000007876015,0.0008494209],"study_design_scores_gemma":[0.00001561547,0.001325118,0.001819641,0.000008482149,0.0000203515,0.0001039769,0.00001378,0.0006505153,0.9953939,0.00002437917,0.0006200675,0.000004055236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892642,0.001967627,0.007067258,0.0000903495,0.00002138638,0.00006190928,0.00006889513,0.0002264504,0.001231995],"genre_scores_gemma":[0.9850894,0.001437356,0.009705784,0.0000495264,0.00001846622,0.00006053051,0.0002434132,0.00005034031,0.0033453],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001659831,"threshold_uncertainty_score":0.005552709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01034436939567813,"score_gpt":0.2231276417595897,"score_spread":0.2127832723639115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}