{"id":"W2093491816","doi":"10.1021/pr300790h","title":"Association of Connexin43 with E3 Ubiquitin Ligase TRIM21 Reveals a Mechanism for Gap Junction Phosphodegron Control","year":2012,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":54,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Ubiquitin ligase; Ubiquitin; Cell biology; Proteasome; Connexin; Immunoprecipitation; Gap junction; Chemistry; Intracellular; Biology; Cell culture; Biochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001825089,0.0002492941,0.0002104159,0.0002443346,0.0003531799,0.0003698164,0.0001829389,0.0004563666,0.0007954172],"category_scores_gemma":[0.0001272007,0.0001420041,0.0003059758,0.0002004656,0.0001999435,0.0003887693,0.0002909062,0.0003910213,0.0004325966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004021826,"about_ca_system_score_gemma":0.0001570842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004702532,"about_ca_topic_score_gemma":0.0005643215,"domain_scores_codex":[0.999868,0.00001838652,0.000009247958,0.00004212739,0.00003145996,0.00003072632],"domain_scores_gemma":[0.9999307,0.000005979904,0.0000219342,0.00001074886,0.00001155036,0.00001900007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007089046,0.00001478717,0.0009583413,0.00002677242,0.00001169896,0.0001466815,0.00001948004,0.00009811053,0.9969158,0.0002825177,0.00006724941,0.001387654],"study_design_scores_gemma":[0.000007561773,0.0001593658,0.05233629,0.00001139367,0.00004779562,0.001354748,0.00009032741,0.00638996,0.9342414,0.0006346839,0.004712304,0.00001406619],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901299,0.003257208,0.004915642,0.0002199264,0.00002896473,0.00001082752,0.0001644233,0.00007786952,0.001195296],"genre_scores_gemma":[0.9944284,0.001334657,0.00243987,0.00007992741,0.00001327186,0.000008968419,0.0002900551,0.000009277594,0.00139553],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007954172,"threshold_uncertainty_score":0.002918065,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04941062104028909,"score_gpt":0.3486968743871143,"score_spread":0.2992862533468252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}