{"id":"W2093503714","doi":"10.1002/jnr.22720","title":"Regulation of P‐glycoprotein by human immunodeficiency virus‐1 in primary cultures of human fetal astrocytes","year":2011,"lang":"en","type":"article","venue":"Journal of Neuroscience Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of Mental Health; National Institute on Alcohol Abuse and Alcoholism; Canadian Institutes of Health Research","keywords":"Downregulation and upregulation; P-glycoprotein; Proinflammatory cytokine; Cytokine; Biology; Tumor necrosis factor alpha; Antibody; Immunology; Secretion; Astrocyte; Cell culture; Pharmacology; Endocrinology; Inflammation; Microbiology; Biochemistry; Multiple drug resistance; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002023004,0.00009850382,0.000366938,0.0005723534,0.0001281179,0.00001161067,0.000412315,0.0000677054,0.00003885811],"category_scores_gemma":[0.0001045604,0.00007098728,0.0001206923,0.0007835692,0.0006133885,0.000256397,0.00004414962,0.0005280158,6.176482e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000738837,"about_ca_system_score_gemma":0.0002123272,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009857799,"about_ca_topic_score_gemma":0.00001290068,"domain_scores_codex":[0.9970953,0.0001221356,0.0007388198,0.0001843371,0.001530227,0.0003291783],"domain_scores_gemma":[0.9988484,0.00002519529,0.0003556564,0.0002193011,0.0004474533,0.0001039574],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002800377,0.0006099405,0.004931121,0.000113074,0.000002955466,0.00004318818,0.000547439,0.000002778921,0.992759,0.0002818122,0.00006570009,0.0003629281],"study_design_scores_gemma":[0.0006301269,0.001622833,0.3291684,0.000244633,0.000007377262,0.0000323771,0.0002054394,0.000009300248,0.667676,0.0002871227,0.00007296419,0.0000434436],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972864,0.000353727,0.0001261607,0.00006428648,0.00006937876,0.0002251538,0.000004025429,0.000003662636,0.001867248],"genre_scores_gemma":[0.9988315,0.0000945018,0.0004655415,0.00001386566,0.00003059146,0.000002335053,0.000001618038,0.00001014708,0.0005499109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.325083,"threshold_uncertainty_score":0.2894777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08045798889285771,"score_gpt":0.3678003489749447,"score_spread":0.287342360082087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}