{"id":"W2093507482","doi":"10.1074/jbc.275.9.6302","title":"Kinetic and Pharmacological Properties of Human Brain Na+/H+ Exchanger Isoform 5 Stably Expressed in Chinese Hamster Ovary Cells","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; National Institutes of Health; Medical Research Council Canada","keywords":"Chinese hamster ovary cell; Gene isoform; Amiloride; Extracellular; Chemistry; Intracellular pH; Sodium–hydrogen antiporter; Stereochemistry; Biochemistry; Sodium; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000194364,0.0001528774,0.0002713214,0.00002257562,0.00002794213,0.000007631055,0.0001341697,0.0002485467,0.0004500115],"category_scores_gemma":[0.00001761996,0.00009503803,0.0001001452,0.00006115367,0.0001582251,0.000008011453,0.00002811067,0.0001577192,5.592835e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000947416,"about_ca_system_score_gemma":0.00001826585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002525449,"about_ca_topic_score_gemma":6.792703e-7,"domain_scores_codex":[0.99907,0.00003526927,0.000433392,0.0001728707,0.0001148407,0.0001735851],"domain_scores_gemma":[0.9996084,0.000009853977,0.0001580807,0.0000831908,0.00006304962,0.00007741235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004398903,0.0001907322,0.00240088,0.00005827731,0.00002563602,0.00001519981,0.00006186468,0.00002972656,0.9960665,3.60196e-7,0.0001243271,0.0005866078],"study_design_scores_gemma":[0.0009990981,0.0003622007,0.01682119,0.00003012541,0.00001659938,0.0000346642,0.00004875238,0.00001667891,0.9806002,0.00003771648,0.000901996,0.0001307767],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984853,0.0009610861,0.00001546759,0.0001399642,0.00002585117,0.00007891023,0.000009843497,0.000003435932,0.0002801001],"genre_scores_gemma":[0.9987461,0.0003543099,0.00006747909,0.0001379828,0.00020537,0.000004490004,0.00002140072,0.000007404464,0.0004554821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0154663,"threshold_uncertainty_score":0.4927311,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01863768180538857,"score_gpt":0.2484306119559928,"score_spread":0.2297929301506043,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}