{"id":"W2093508765","doi":"10.1021/jm3008954","title":"Crystal Structure of Human Aurora B in Complex with INCENP and VX-680","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Chemistry; Xenopus; Aurora B kinase; Protein kinase domain; Kinase; Cell biology; Aurora kinase; Biochemistry; Biology; Cell cycle; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001146995,0.0003017624,0.0005268882,0.0001692472,0.0006088481,0.000518839,0.0006789694,0.0004257683,0.001531957],"category_scores_gemma":[0.0002365143,0.0002653482,0.0001443031,0.0003093374,0.0002133075,0.0002320753,0.0002201412,0.001057469,0.0002649495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008897209,"about_ca_system_score_gemma":0.0006427786,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006544162,"about_ca_topic_score_gemma":0.008210388,"domain_scores_codex":[0.9999114,0.000008920368,0.000003805588,0.0000175311,0.00003817829,0.00002014031],"domain_scores_gemma":[0.999907,0.00002890542,0.0000184197,0.000003949133,0.00001277741,0.00002890523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00331154,0.001323667,0.0154201,0.001064831,0.0005350942,0.005488089,0.001470308,0.01186716,0.9080901,0.004586363,0.01492658,0.03191621],"study_design_scores_gemma":[0.00222732,0.001627434,0.1324831,0.0002853124,0.000508751,0.01002002,0.003032491,0.165115,0.5530048,0.003010409,0.1283323,0.0003531315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904696,0.003194819,0.001043153,0.0004910412,0.00006268062,0.0000244892,0.0008590912,0.0001620033,0.003693037],"genre_scores_gemma":[0.9853078,0.002451067,0.003809903,0.0002346834,0.00002470678,0.0000441563,0.004398702,0.00004453883,0.00368436],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006544162,"threshold_uncertainty_score":0.01301217,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008185707045371844,"score_gpt":0.2511211931905905,"score_spread":0.2429354861452187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}