{"id":"W2093508765","doi":"10.1021/jm3008954","title":"Crystal Structure of Human Aurora B in Complex with INCENP and VX-680","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; Wellcome Trust","keywords":"Chemistry; Xenopus; Aurora B kinase; Protein kinase domain; Kinase; Cell biology; Aurora kinase; Biochemistry; Biology; Cell cycle; Apoptosis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001473297,0.0001093169,0.000218372,0.00002615053,0.00002049513,0.000004047995,0.0001188286,0.0001162237,0.00004466732],"category_scores_gemma":[0.00002924956,0.00008185554,0.00003638413,0.00004719246,0.0001292505,0.000006364971,0.00004245036,0.000204591,4.90578e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001573644,"about_ca_system_score_gemma":0.00005832897,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007545348,"about_ca_topic_score_gemma":0.000009989555,"domain_scores_codex":[0.9992818,0.00001680906,0.0002904965,0.0000851408,0.0001633882,0.0001623591],"domain_scores_gemma":[0.9994151,0.000007038874,0.0002625008,0.0001124376,0.00008351723,0.0001194201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001234218,0.00005454493,0.04094343,0.0001087889,0.00003643704,0.000007987686,0.0001086303,0.000004192886,0.9580546,0.000004824331,0.0003615505,0.0001915988],"study_design_scores_gemma":[0.001625765,0.0004021744,0.02825921,0.00013464,0.00005307351,0.001016367,0.0005880572,0.000005629011,0.9651128,0.0000247824,0.002640855,0.0001366105],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998278,0.001214796,0.00007239138,0.00005133788,0.00002505527,0.0000317096,0.000009511096,8.258477e-7,0.0003163808],"genre_scores_gemma":[0.9989157,0.0000889904,0.00046678,0.00006618675,0.0003891137,2.588351e-7,0.00002379598,0.00001000664,0.00003919769],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01268421,"threshold_uncertainty_score":0.3337972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008185707045371844,"score_gpt":0.2511211931905905,"score_spread":0.2429354861452187,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}