{"id":"W2093563015","doi":"10.1016/j.ydbio.2015.03.014","title":"Ras/MEK/MAPK-mediated regulation of heparin sulphate proteoglycans promotes retinal fate in the Drosophila eye–antennal disc","year":2015,"lang":"en","type":"article","venue":"Developmental Biology","topic":"Hippo pathway signaling and YAP/TAZ","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Imaginal disc; Cell biology; MAPK/ERK pathway; Hedgehog; Retinal; Hedgehog signaling pathway; Phenotype; Eye development; Signal transduction; Fibroblast growth factor; Anatomy; Genetics; Receptor; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007358411,0.0001942775,0.0002169637,0.0000770456,0.00005941436,0.0000123632,0.0002855492,0.0002122277,0.00001177633],"category_scores_gemma":[0.0001966343,0.0001398959,0.00005493822,0.0001955701,0.0002206731,0.000005865252,0.0001087921,0.0001348546,0.00002727167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000335534,"about_ca_system_score_gemma":0.000226435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008480526,"about_ca_topic_score_gemma":0.00009384043,"domain_scores_codex":[0.9985113,0.0002608622,0.0004039406,0.0003650963,0.0001366271,0.0003221832],"domain_scores_gemma":[0.9994726,0.0000220384,0.0001528346,0.0001880177,0.00009182472,0.0000727486],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002038694,0.00008311865,0.04894401,0.00001224981,0.00002680771,0.000005739497,0.0006160139,0.000005175018,0.9493453,0.0001300925,0.00005604818,0.0005715946],"study_design_scores_gemma":[0.00188195,0.000771308,0.07666959,0.00006518552,0.00001384463,0.00007534302,0.0006389529,0.0001450768,0.9102297,0.001014419,0.008070161,0.0004244497],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982058,0.0001642973,0.0001740285,0.0003732491,0.0001191204,0.0004056428,0.00004187729,0.0000192022,0.0004967317],"genre_scores_gemma":[0.9975598,0.00002415027,0.001111807,0.0001316056,0.00009022123,0.0000713156,0.0008079374,0.00001923125,0.0001839067],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03911556,"threshold_uncertainty_score":0.5704791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02404920277132684,"score_gpt":0.2613986008569227,"score_spread":0.2373493980855958,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}