{"id":"W2093565876","doi":"10.1089/oli.2006.16.2","title":"Adenovirus-Delivered Antisense RNA and shRNA Exhibit Different Silencing Efficiencies for the Endogenous Transforming Growth Factor- <i>β</i> (TGF- <i>β</i> ) Type II Receptor","year":2006,"lang":"en","type":"article","venue":"Oligonucleotides","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut National de la Recherche Scientifique; Université de Montréal; Biotechnology Research Institute","funders":"","keywords":"Small hairpin RNA; Biology; Gene silencing; RNA interference; Small interfering RNA; RNA; Molecular biology; RNA silencing; Antisense RNA; Trans-acting siRNA; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004288065,0.0005148248,0.0004128099,0.000282026,0.0001068878,0.0004237541,0.0002095202,0.0003360001,0.0006952434],"category_scores_gemma":[0.000253532,0.0002100378,0.0003180981,0.0002195643,0.0003108371,0.0002211145,0.000154752,0.0005450329,0.000296602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003648187,"about_ca_system_score_gemma":0.0002533092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005102049,"about_ca_topic_score_gemma":0.0008484315,"domain_scores_codex":[0.999581,0.00006988828,0.00008622515,0.00007818179,0.0001309354,0.00005364707],"domain_scores_gemma":[0.9997547,0.0000831814,0.00006153309,0.00002994231,0.00003687957,0.00003386727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002968793,0.00001953999,0.0001249508,0.00002723564,0.000006576597,0.000009541646,0.000008040467,0.00004428322,0.9989578,0.00006195917,0.00001220439,0.0006983158],"study_design_scores_gemma":[0.00001005059,0.0002899164,0.001008232,0.000002680056,0.00002376703,0.00009385854,0.00001113557,0.0003311066,0.9971992,0.0000165829,0.00100995,0.000003523223],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9860014,0.0029449,0.00855772,0.00007075554,0.00005347408,0.00008379023,0.0004746307,0.0001493341,0.001663912],"genre_scores_gemma":[0.9724396,0.002347038,0.02055372,0.000102424,0.00001400351,0.0001391964,0.001544992,0.0000751228,0.002783938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006952434,"threshold_uncertainty_score":0.002646983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02207786907346228,"score_gpt":0.246418401699793,"score_spread":0.2243405326263307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}