{"id":"W2093565876","doi":"10.1089/oli.2006.16.2","title":"Adenovirus-Delivered Antisense RNA and shRNA Exhibit Different Silencing Efficiencies for the Endogenous Transforming Growth Factor- <i>β</i> (TGF- <i>β</i> ) Type II Receptor","year":2006,"lang":"en","type":"article","venue":"Oligonucleotides","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Institut National de la Recherche Scientifique; Université de Montréal; Biotechnology Research Institute","funders":"","keywords":"Small hairpin RNA; Biology; Gene silencing; RNA interference; Small interfering RNA; RNA; Molecular biology; RNA silencing; Antisense RNA; Trans-acting siRNA; Cell biology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000263734,0.0003468865,0.0002772754,0.00007055995,0.0008034162,0.0001090858,0.0003780418,0.0001422935,0.00005439044],"category_scores_gemma":[0.00008764221,0.0002561276,0.0001673899,0.0001617045,0.0002661626,0.00001569392,0.0001505812,0.0001586255,0.000009333166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003831548,"about_ca_system_score_gemma":0.00008047034,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000193749,"about_ca_topic_score_gemma":0.0002429034,"domain_scores_codex":[0.9981034,0.00007813533,0.0003310158,0.0005417193,0.0002934013,0.0006523055],"domain_scores_gemma":[0.9990478,0.0001353923,0.00009788531,0.0003935666,0.0002104635,0.0001148987],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009881633,0.00008936448,0.0003938657,0.00004527084,0.00007271853,0.000003039371,0.0002274194,0.00007796316,0.9897407,0.00003793704,0.0009016306,0.007421887],"study_design_scores_gemma":[0.0009888482,0.002038037,0.0005500072,0.00002761466,0.00004061908,0.00002574252,0.0001924167,0.0001428259,0.9914085,0.00005628396,0.004185345,0.0003437159],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900983,0.007722137,0.0004059147,0.0002409187,0.0001801182,0.0007801497,0.0001479012,0.00004553275,0.000379058],"genre_scores_gemma":[0.9955567,0.003177956,0.0001986913,0.0002650552,0.0003820224,0.00004607751,0.00007959214,0.00007315036,0.0002207626],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007078172,"threshold_uncertainty_score":0.9999891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02207786907346228,"score_gpt":0.246418401699793,"score_spread":0.2243405326263307,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}