{"id":"W20935937","doi":"10.1038/35055010","title":"Reversible disruption of pericentric heterochromatin and centromere function by inhibiting deacetylases","year":2001,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":356,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Ligue Contre le Cancer; Ministère de l'Éducation et de l'Enseignement supérieur; Ministère de l'Éducation Nationale","keywords":"Heterochromatin; Centromere; Heterochromatin protein 1; Cell biology; Biology; Interphase; Chromatin; Mitosis; Chromosome segregation; Histone; Euchromatin; Histone deacetylase; Genetics; Chromosome; DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002119134,0.0004144536,0.0003982108,0.0002613592,0.000238115,0.0005289022,0.000910337,0.0003603266,0.002020969],"category_scores_gemma":[0.0002399745,0.0003416986,0.0002885941,0.0002111319,0.0005603501,0.0003003688,0.0003318154,0.0009019816,0.0004249835],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007496654,"about_ca_system_score_gemma":0.0003304966,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001274938,"about_ca_topic_score_gemma":0.002427103,"domain_scores_codex":[0.9997934,0.00001596302,0.00002123792,0.00005574694,0.00005664562,0.00005710515],"domain_scores_gemma":[0.9997602,0.00005735026,0.00006355625,0.00006407917,0.00001525018,0.00003962083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001842309,0.00003581238,0.00009229912,0.00003514362,0.00001530795,0.0000373037,0.000009898316,0.0002249884,0.9970822,0.0008075475,0.00006125329,0.00141398],"study_design_scores_gemma":[0.0000247151,0.00004950344,0.000427439,0.000001357275,0.000009633413,0.00005404776,0.000006450161,0.0005344448,0.9975436,0.00006708997,0.001278532,0.000003110124],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840296,0.002602009,0.007643036,0.0002463075,0.0001354136,0.00004832938,0.0004150246,0.0004202894,0.004460112],"genre_scores_gemma":[0.995484,0.0005565781,0.001325317,0.00005420389,0.00001229038,0.0000191854,0.0001923609,0.000060592,0.00229551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002020969,"threshold_uncertainty_score":0.006760776,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00265944021807475,"score_gpt":0.2045333866291407,"score_spread":0.201873946411066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}