{"id":"W2093638076","doi":"10.1073/pnas.1202130109","title":"Knockout of the prion protein (PrP)-like <i>Sprn</i> gene does not produce embryonic lethality in combination with PrP <sup>C</sup> -deficiency","year":2012,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; U.S. Public Health Service","keywords":"Biology; PRNP; Gene knockdown; Gene; Molecular biology; Genetics; Gene targeting; Synthetic lethality; Knockout mouse; Phenotype; Mutant; Allele; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001508522,0.0005024255,0.0002436337,0.0004098254,0.000180666,0.0003229949,0.0003812163,0.0003446782,0.001943756],"category_scores_gemma":[0.0001479159,0.0002227697,0.0003023669,0.0001237488,0.0004019762,0.0001984521,0.000401438,0.0007520503,0.0006785803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001961699,"about_ca_system_score_gemma":0.0001940627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004483304,"about_ca_topic_score_gemma":0.001156242,"domain_scores_codex":[0.9997544,0.00003105002,0.00003781828,0.00006321476,0.00008573046,0.00002792945],"domain_scores_gemma":[0.9995764,0.0001010276,0.000130685,0.00004948657,0.00002912444,0.0001133498],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000379625,0.00001132348,0.0002464108,0.0000160204,0.000003738483,0.0001002812,0.00001074601,0.00002698319,0.9989396,0.00009616202,0.00002233137,0.0004884963],"study_design_scores_gemma":[0.00001510906,0.0001937969,0.008142462,0.00001394606,0.00002389596,0.001289078,0.00003374054,0.0006563811,0.9864472,0.0000888177,0.003084122,0.00001149717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875908,0.0005209091,0.006987758,0.0001103623,0.00002776803,0.00003321145,0.001527416,0.0002030804,0.002998704],"genre_scores_gemma":[0.9766248,0.0008964443,0.00876704,0.0001022756,0.00001281502,0.00006604342,0.003187017,0.0001972258,0.01014635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001943756,"threshold_uncertainty_score":0.006502569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01834771777093569,"score_gpt":0.2679301645551119,"score_spread":0.2495824467841762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}