{"id":"W2093642223","doi":"10.1371/journal.ppat.1003755","title":"Infectious Prions Accumulate to High Levels in Non Proliferative C2C12 Myotubes","year":2013,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Alberta Prion Research Institute; University of Alberta","keywords":"Myogenesis; C2C12; Hamster; Infectivity; Biology; Myocyte; Cell biology; Cell culture; Gene isoform; In vitro; Virology; Mitosis; Molecular biology; Biochemistry; Virus; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003064773,0.000406488,0.0005823078,0.0004663404,0.0003742948,0.0005489502,0.0003032942,0.0004516067,0.0007967835],"category_scores_gemma":[0.0001998518,0.0002775167,0.000328956,0.000282439,0.0002762853,0.000238701,0.0003211704,0.00091577,0.000803557],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004790312,"about_ca_system_score_gemma":0.0003307873,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002764463,"about_ca_topic_score_gemma":0.004837467,"domain_scores_codex":[0.99966,0.0000395809,0.00005112097,0.00007784942,0.0001232998,0.00004803818],"domain_scores_gemma":[0.9995611,0.0001134756,0.0000577038,0.00006826112,0.0001130986,0.00008641474],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002512559,0.00001376653,0.0001446925,0.00003324029,0.000003614076,0.00007742933,0.00003830231,0.00001215787,0.999119,0.00004519541,0.00003299372,0.0004546322],"study_design_scores_gemma":[0.00001379491,0.0004466602,0.01946802,0.000024241,0.00002705827,0.0005606927,0.0001143912,0.0004812592,0.9754194,0.00009202694,0.003341598,0.00001085128],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9792423,0.005248318,0.007550612,0.0001722552,0.00008873188,0.00007684796,0.001443686,0.0001923906,0.005984883],"genre_scores_gemma":[0.9691439,0.003206047,0.01170793,0.0001454599,0.00004913981,0.00009416026,0.002432753,0.00009347117,0.01312723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002764463,"threshold_uncertainty_score":0.00549674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01438208409582502,"score_gpt":0.2553010221438327,"score_spread":0.2409189380480077,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}