{"id":"W2093657927","doi":"10.1016/j.ymgme.2007.08.024","title":"19 Pyrimethamine as a potential pharmacological chaperone for late-onset forms of GM2 gangliosidosis","year":2007,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Gangliosidosis; Medicine; Neuroscience; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003436719,0.000177823,0.0003485516,0.000108402,0.00009561197,0.000006591805,0.0001366319,0.0002794504,0.0001200271],"category_scores_gemma":[0.00003991969,0.0001436276,0.0001330214,0.000108266,0.0002180011,0.00001302846,0.00009089941,0.0001315975,0.000007518704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000709526,"about_ca_system_score_gemma":0.00003775869,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000036196,"about_ca_topic_score_gemma":0.000006047244,"domain_scores_codex":[0.9988968,0.00005403581,0.000296812,0.0002998165,0.00003746141,0.000415011],"domain_scores_gemma":[0.9995524,0.00004344233,0.0001140491,0.0001467534,0.00009334603,0.00004999729],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003100441,0.0001035343,0.0002310491,0.00001406757,0.0002451513,0.00001026883,0.0001042513,0.000007640278,0.9799152,0.001126576,0.0001432915,0.01778894],"study_design_scores_gemma":[0.002605797,0.0004257443,0.01080227,0.000003916005,0.0002989855,0.00009398875,0.00006604311,0.00001051593,0.9386904,0.001803119,0.0450115,0.0001877379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9550182,0.03833212,0.005309069,0.0001237065,0.0005221425,0.0003483253,0.00006476344,0.00001881691,0.0002628315],"genre_scores_gemma":[0.9967521,0.001293778,0.0008136785,0.0006797574,0.0000534074,0.00002913189,0.00007224193,0.00001824373,0.0002876592],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04486821,"threshold_uncertainty_score":0.5856965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008266869180792584,"score_gpt":0.2679320448646474,"score_spread":0.2596651756838548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}