{"id":"W2093694324","doi":"10.4161/cc.4.7.1830","title":"Methylation of MRE11 Regulates its Nuclear Compartmentalization","year":2005,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Biology; DNA damage; DNA repair; Rad50; DNA methylation; Chromatin; Cell biology; Nuclear protein; Methylation; DNA; Molecular biology; Arginine; Genetics; DNA-binding protein; Gene; Amino acid; Transcription factor; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006149176,0.00007203444,0.00007532723,0.00002996886,0.00003790974,0.000006566369,0.00006078854,0.00009058617,0.00009969787],"category_scores_gemma":[0.000006932251,0.00007979532,0.00004539949,0.00007424485,0.00002480053,0.000006457597,0.00002922174,0.00002371675,0.00003305109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002364675,"about_ca_system_score_gemma":0.00001404709,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005051972,"about_ca_topic_score_gemma":0.000009736387,"domain_scores_codex":[0.9994802,0.0000267226,0.000160084,0.0001558598,0.0000853118,0.00009184868],"domain_scores_gemma":[0.9996481,0.000003213266,0.00009958681,0.0001646512,0.00005459242,0.00002988141],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002911181,0.00004408071,0.0001920822,0.00001217486,0.00001220284,4.030327e-8,0.00006057873,0.02300554,0.9719773,0.00008807397,0.001364088,0.003214738],"study_design_scores_gemma":[0.0003618881,0.00006159709,0.002065453,0.000005969383,0.00001518384,0.00000116435,0.00001950841,0.01268846,0.9554663,0.00003295203,0.0291961,0.0000853868],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947757,0.000956496,0.0005041006,0.00008612623,0.00007370237,0.0001276362,0.000006037336,0.00001424463,0.003455963],"genre_scores_gemma":[0.9984201,0.00008866507,0.0005081189,0.0000345522,0.0001551644,0.000002705304,0.0001891472,0.0000177297,0.0005838638],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02783201,"threshold_uncertainty_score":0.3253959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006303790637563842,"score_gpt":0.228165501907212,"score_spread":0.2218617112696481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}