{"id":"W2093694324","doi":"10.4161/cc.4.7.1830","title":"Methylation of MRE11 Regulates its Nuclear Compartmentalization","year":2005,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Biology; DNA damage; DNA repair; Rad50; DNA methylation; Chromatin; Cell biology; Nuclear protein; Methylation; DNA; Molecular biology; Arginine; Genetics; DNA-binding protein; Gene; Amino acid; Transcription factor; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001199937,0.0001942322,0.0001913877,0.0001372787,0.0001686565,0.0004336865,0.0001390802,0.0001708158,0.0009315379],"category_scores_gemma":[0.0001768655,0.0001548519,0.0001463397,0.0001026558,0.000221136,0.0002511274,0.000204273,0.0003184243,0.0007271913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003490893,"about_ca_system_score_gemma":0.0001351865,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005313579,"about_ca_topic_score_gemma":0.0008604361,"domain_scores_codex":[0.9998653,0.00002261194,0.00000831436,0.00004547414,0.0000263753,0.00003188926],"domain_scores_gemma":[0.9998732,0.00001867025,0.00003742936,0.00001868282,0.0000271124,0.00002495959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000637762,0.000003824007,0.0003228304,0.00001082975,0.000001970173,0.0000195009,0.00001394226,0.0000293169,0.998444,0.00007926986,0.00001591013,0.0009947576],"study_design_scores_gemma":[0.00000651725,0.00005951653,0.009906002,0.000003446772,0.000008069055,0.0002003651,0.0000348022,0.0006276445,0.9856117,0.00006988839,0.003467578,0.000004494829],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893043,0.003983739,0.004649736,0.0001448769,0.00002073844,0.00001013275,0.000147856,0.00008974995,0.001648797],"genre_scores_gemma":[0.9960541,0.0007877977,0.001091119,0.0000197288,0.000005620241,0.000005414209,0.0001744492,0.00001688556,0.001844986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009315379,"threshold_uncertainty_score":0.00311631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006303790637563842,"score_gpt":0.228165501907212,"score_spread":0.2218617112696481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}