{"id":"W2093744073","doi":"10.1002/pmic.200601006","title":"Systematic identification of SH3 domain‐mediated human protein–protein interactions by peptide array target screening","year":2007,"lang":"en","type":"article","venue":"PROTEOMICS","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Western University","funders":"","keywords":"SH3 domain; Interactome; Protein–protein interaction; Computational biology; Peptide; Biology; Phosphotyrosine-binding domain; Immunoprecipitation; Proto-oncogene tyrosine-protein kinase Src; SH2 domain; Protein domain; GRB2; Cell biology; Genetics; Biochemistry; Kinase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006340079,0.0007948705,0.0009356813,0.0007611742,0.0003058072,0.0004542845,0.0003964468,0.0003358973,0.001503269],"category_scores_gemma":[0.0005671708,0.0003609889,0.0004556407,0.0008214583,0.0002088925,0.0002692598,0.0006704706,0.0004607245,0.001121103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002584434,"about_ca_system_score_gemma":0.0002568852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002152218,"about_ca_topic_score_gemma":0.0005384563,"domain_scores_codex":[0.9993321,0.000160368,0.00006087032,0.0001315908,0.0002341175,0.00008086865],"domain_scores_gemma":[0.999671,0.0001414104,0.00006076079,0.00003628362,0.00005328969,0.0000372744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008826027,0.00003659265,0.0004378803,0.00004898174,0.0000132477,0.00008688156,0.00001222373,0.0003042371,0.9952477,0.00005193257,0.0000981122,0.00357396],"study_design_scores_gemma":[0.00002402807,0.0003969401,0.003725961,0.000005116887,0.00003750547,0.0005884774,0.00002593277,0.007255165,0.9853795,0.00008420041,0.002464199,0.00001289299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8968124,0.002782671,0.09278589,0.000181945,0.00004747393,0.0006319971,0.002622361,0.001140707,0.002994456],"genre_scores_gemma":[0.8933631,0.00241097,0.09317554,0.0002450413,0.00003306464,0.0006275738,0.006771994,0.0001562166,0.003216674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001503269,"threshold_uncertainty_score":0.005028903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006574217395821619,"score_gpt":0.2368834590190929,"score_spread":0.2303092416232712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}