{"id":"W2093744073","doi":"10.1002/pmic.200601006","title":"Systematic identification of SH3 domain‐mediated human protein–protein interactions by peptide array target screening","year":2007,"lang":"en","type":"article","venue":"PROTEOMICS","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; Western University","funders":"","keywords":"SH3 domain; Interactome; Protein–protein interaction; Computational biology; Peptide; Biology; Phosphotyrosine-binding domain; Immunoprecipitation; Proto-oncogene tyrosine-protein kinase Src; SH2 domain; Protein domain; GRB2; Cell biology; Genetics; Biochemistry; Kinase; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001042603,0.0001836021,0.0002482998,0.00007371284,0.0001455413,0.00004335013,0.0002552309,0.0001674331,0.0000112665],"category_scores_gemma":[0.00009735101,0.0001791698,0.0001109784,0.0001198986,0.00008003546,0.00001342912,0.00006559555,0.000176655,0.00001325319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003064736,"about_ca_system_score_gemma":0.00003164023,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000185477,"about_ca_topic_score_gemma":0.00001934603,"domain_scores_codex":[0.9983447,0.00005266971,0.0009141659,0.0002366526,0.0001640333,0.0002877993],"domain_scores_gemma":[0.998673,0.00001251935,0.0006579821,0.0004268995,0.000138974,0.00009064659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004314808,0.00005149433,0.0001106562,0.0009788675,0.00008060915,3.700718e-7,0.0001209643,0.0000298159,0.9980427,0.0002265035,0.0002513409,0.0000635123],"study_design_scores_gemma":[0.0004182338,0.0001104995,0.0001173873,0.0005326326,0.00001911006,0.000007163246,0.0002695814,0.0002989773,0.9962692,0.0008711764,0.0008426031,0.0002434355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5124623,0.0001422803,0.4853635,0.00003960449,0.00005024779,0.00143652,0.00003743447,0.00001502552,0.0004530493],"genre_scores_gemma":[0.9684209,0.000004499356,0.02982765,0.00003679634,0.0001275784,0.0001930297,0.0004489478,0.00003076898,0.0009098262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4559586,"threshold_uncertainty_score":0.7306333,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006574217395821619,"score_gpt":0.2368834590190929,"score_spread":0.2303092416232712,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}