{"id":"W2093814179","doi":"10.1021/jm060102l","title":"Effect of Various Pyrimidines Possessing the 1-[(2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl] Moiety, Able To Mimic Natural 2‘-Deoxyribose, on Wild-type and Mutant Hepatitis B Virus Replication","year":2006,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Moiety; Deoxyribose; Mutant; Hydroxymethyl; Stereochemistry; Alkoxy group; Nucleic acid; Virology; Biochemistry; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001720169,0.0002808548,0.0002191343,0.0001744773,0.0001032758,0.0001749142,0.0002107405,0.000208723,0.001159994],"category_scores_gemma":[0.0002245112,0.0001236351,0.0001830445,0.0001562595,0.0001485694,0.0001492893,0.00012395,0.0003926355,0.0001724804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009274107,"about_ca_system_score_gemma":0.0001500228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007802314,"about_ca_topic_score_gemma":0.00139309,"domain_scores_codex":[0.9998925,0.00003249997,0.00001227554,0.00001794716,0.00002280543,0.0000220119],"domain_scores_gemma":[0.9998441,0.00005092919,0.00003468429,0.00001078345,0.00001497655,0.00004449823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002316952,0.000589275,0.0004530399,0.000278982,0.00003589633,0.0001403925,0.00008691533,0.0008514795,0.9853215,0.0001246145,0.0001020352,0.00969889],"study_design_scores_gemma":[0.0001620931,0.01394525,0.002335467,0.00002503445,0.00005217936,0.0001646906,0.00003536542,0.0008725799,0.9801077,0.00002371792,0.002259568,0.00001644131],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953731,0.003190862,0.0001417722,0.00002426762,0.00002625445,0.00001721106,0.0001238004,0.0000201257,0.001082715],"genre_scores_gemma":[0.9954556,0.002303872,0.0007160946,0.00003996146,0.00001398724,0.00001100749,0.0002749744,0.000007591041,0.001176825],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001159994,"threshold_uncertainty_score":0.00388056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008167768053011424,"score_gpt":0.2917063297059578,"score_spread":0.2835385616529463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}