{"id":"W2093814179","doi":"10.1021/jm060102l","title":"Effect of Various Pyrimidines Possessing the 1-[(2-Hydroxy-1-(hydroxymethyl)ethoxy)methyl] Moiety, Able To Mimic Natural 2‘-Deoxyribose, on Wild-type and Mutant Hepatitis B Virus Replication","year":2006,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Chemistry; Moiety; Deoxyribose; Mutant; Hydroxymethyl; Stereochemistry; Alkoxy group; Nucleic acid; Virology; Biochemistry; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"bench_or_experimental","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00214408,0.0003504288,0.0009610594,0.0001330645,0.0001894536,0.00003072835,0.0002522942,0.0001810353,0.00003768261],"category_scores_gemma":[0.003172443,0.000219698,0.0001735982,0.0005347394,0.0002807087,0.0001063395,0.00008850962,0.0008804096,0.000003795648],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000265883,"about_ca_system_score_gemma":0.0002288335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002385092,"about_ca_topic_score_gemma":0.0001039968,"domain_scores_codex":[0.9970685,0.0001602278,0.0009914525,0.0003673445,0.001018063,0.0003943955],"domain_scores_gemma":[0.9969074,0.0009094477,0.0007732665,0.0005508037,0.0006284802,0.000230564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001137038,0.0001335077,0.03060383,0.0006216246,0.0002051489,0.0002519343,0.0003072449,0.00008203061,0.9554856,0.000006472106,0.003005656,0.008159929],"study_design_scores_gemma":[0.001856849,0.002345206,0.03837328,0.001652909,0.0006718663,0.002032563,0.00006000567,0.0004713064,0.9504177,0.0001169417,0.001778595,0.0002227781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897326,0.005592863,0.0000723081,0.002941431,0.0003149898,0.0003217694,0.000009808919,0.00002555611,0.000988657],"genre_scores_gemma":[0.9962585,0.001320309,0.000554939,0.0005276878,0.0009901471,0.000009016742,0.00001046146,0.00004162576,0.0002873109],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007937151,"threshold_uncertainty_score":0.8959024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008167768053011424,"score_gpt":0.2917063297059578,"score_spread":0.2835385616529463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}