{"id":"W2093817896","doi":"10.1111/febs.12733","title":"Human steroid and oxysterol 7α‐hydroxylase <scp>CYP</scp>7B1: substrate specificity, azole binding and misfolding of clinically relevant mutants","year":2014,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; Genome Canada","keywords":"Oxysterol; Hydroxylation; Cytochrome P450; Steroid; Pregnenolone; Monooxygenase; Chemistry; Biochemistry; Azole; Sterol; Enzyme; Stereochemistry; Biology; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001736506,0.000393466,0.0002372285,0.0001535027,0.0001085855,0.0001907439,0.0002096663,0.0002906797,0.001527367],"category_scores_gemma":[0.000199003,0.0001209604,0.0003428808,0.0001789749,0.0002411512,0.00008712217,0.0001226538,0.0004653568,0.0005908667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003067936,"about_ca_system_score_gemma":0.0001599499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001315292,"about_ca_topic_score_gemma":0.0006355134,"domain_scores_codex":[0.9997894,0.0000496853,0.00002946481,0.00004428024,0.00006198876,0.00002524911],"domain_scores_gemma":[0.9998602,0.00003181331,0.00004003498,0.00001972382,0.00001614987,0.00003208075],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002376332,0.00005676744,0.0005722602,0.00003824997,0.00002716872,0.0003191186,0.00002183289,0.0001792549,0.9964367,0.0001382265,0.0001424189,0.00183038],"study_design_scores_gemma":[0.00004400632,0.0002667791,0.005866774,0.000005925242,0.00004284653,0.001823739,0.0000225794,0.001676951,0.9849983,0.00005043474,0.005193923,0.000007757569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930329,0.0009936115,0.003733551,0.0002012429,0.00004635173,0.0000398828,0.001168184,0.00007167103,0.0007125338],"genre_scores_gemma":[0.990833,0.0006010533,0.002931628,0.00006590501,0.00001825302,0.00004148336,0.002884389,0.00007925944,0.002544888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001527367,"threshold_uncertainty_score":0.005109549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03431156853293579,"score_gpt":0.2943696344018329,"score_spread":0.2600580658688971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}