{"id":"W2093817896","doi":"10.1111/febs.12733","title":"Human steroid and oxysterol 7α‐hydroxylase <scp>CYP</scp>7B1: substrate specificity, azole binding and misfolding of clinically relevant mutants","year":2014,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Hormonal Regulation and Hypertension","field":"Medicine","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; Knut och Alice Wallenbergs Stiftelse; Stiftelsen för Strategisk Forskning; Genome Canada","keywords":"Oxysterol; Hydroxylation; Cytochrome P450; Steroid; Pregnenolone; Monooxygenase; Chemistry; Biochemistry; Azole; Sterol; Enzyme; Stereochemistry; Biology; Cholesterol","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001248059,0.000175633,0.0004983198,0.0002163982,0.0002337149,0.00008346794,0.00007673997,0.0001314534,0.00003669191],"category_scores_gemma":[0.0003899728,0.0001386602,0.00009048452,0.00009474836,0.0001451876,0.0001444457,0.00005805611,0.0004250248,0.0000130634],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003134894,"about_ca_system_score_gemma":0.00003977155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004887123,"about_ca_topic_score_gemma":0.000008115545,"domain_scores_codex":[0.9981256,0.0001132054,0.0008221853,0.0002370635,0.0004193522,0.0002825766],"domain_scores_gemma":[0.9986209,0.0002095204,0.0004230367,0.0001683363,0.0001642174,0.0004139913],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.000153728,0.0001658469,0.1443673,0.000125072,0.0001188096,0.0002941143,0.000676069,0.00001157668,0.8436334,0.0001833063,0.0007279993,0.009542881],"study_design_scores_gemma":[0.01004777,0.002661976,0.9322777,0.001691061,0.0003806908,0.008949182,0.001240707,0.005620851,0.02906401,0.001010824,0.006813637,0.0002415639],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977043,0.0003886728,0.0001834652,0.0002729129,0.0001418933,0.000136599,0.000004557386,0.00001906326,0.001148526],"genre_scores_gemma":[0.9980227,0.0002940936,0.0006264269,0.000190963,0.0003716962,6.564909e-7,0.000003778062,0.00002678257,0.0004628899],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8145693,"threshold_uncertainty_score":0.5654398,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03431156853293579,"score_gpt":0.2943696344018329,"score_spread":0.2600580658688971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}