{"id":"W2093839470","doi":"10.1016/j.jhep.2005.11.043","title":"Endogenous opioid-mediated antinociception in cholestatic mice is peripherally, not centrally, mediated","year":2005,"lang":"en","type":"article","venue":"Journal of Hepatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Heritage Foundation for Medical Research","keywords":"(+)-Naloxone; Endogenous opioid; Cholestasis; Enkephalin; Medicine; Opiate; Opioid; Nociception; Opioid peptide; Endorphins; Pharmacology; Antagonist; Opioid receptor; Endocrinology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002590478,0.0001897192,0.0007077584,0.0003446072,0.00004762801,0.00000952316,0.0001681168,0.000251841,0.0008489043],"category_scores_gemma":[0.0003640982,0.0001618482,0.0001739826,0.0002160515,0.0001508104,0.0001796478,0.00002435859,0.0004909344,0.000163273],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001261639,"about_ca_system_score_gemma":0.0004268099,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003109508,"about_ca_topic_score_gemma":0.00004791575,"domain_scores_codex":[0.9980065,0.0002009842,0.000898858,0.0001824293,0.0002734026,0.0004377786],"domain_scores_gemma":[0.9987016,0.0002497097,0.0004326274,0.0001564986,0.000208933,0.0002506759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001514963,0.001049049,0.9216827,0.0001365925,0.0002114169,0.004554658,0.002184778,0.00001712073,0.05365021,0.0000189028,0.01243541,0.002544247],"study_design_scores_gemma":[0.01982651,0.0009420802,0.8470404,0.00037681,0.0005958818,0.04985477,0.0007674078,0.002193953,0.01989524,0.0001608835,0.05774996,0.0005961022],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869896,0.001853616,0.00002811122,0.00978131,0.000311589,0.0001764176,0.00001394248,0.00002348144,0.0008219731],"genre_scores_gemma":[0.9888542,0.001217029,0.000876749,0.008751271,0.0001727528,0.000003684342,0.00003233362,0.00002090562,0.00007104981],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07464227,"threshold_uncertainty_score":0.9294906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0215475432269149,"score_gpt":0.2759972317830608,"score_spread":0.2544496885561459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}