{"id":"W2093844741","doi":"10.1371/journal.pone.0088087","title":"Pharmacological AMP Kinase Activators Target the Nucleolar Organization and Control Cell Proliferation","year":2014,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Heart and Stroke Foundation of Canada","keywords":"Fibrillarin; Nucleolin; Nucleolus; Ribosome biogenesis; Cell biology; Nucleophosmin; Biology; Mitochondrial biogenesis; Cell growth; Phenformin; AMPK; Protein kinase A; Chemistry; Kinase; Mitochondrion; Ribosome; RNA; Biochemistry; Cytoplasm","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001072333,0.0003289961,0.0002518174,0.0002444085,0.0002091924,0.000373566,0.0001788911,0.0003093577,0.002005752],"category_scores_gemma":[0.000121283,0.000117639,0.0002989099,0.0001873455,0.0002295054,0.0002397303,0.0001638781,0.0004396036,0.0006366631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002596544,"about_ca_system_score_gemma":0.0001475067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002271586,"about_ca_topic_score_gemma":0.0004670372,"domain_scores_codex":[0.9998785,0.00002093546,0.00001329228,0.00003320461,0.00002875215,0.00002530187],"domain_scores_gemma":[0.9999163,0.00001812961,0.00002796017,0.00001108283,0.00001203782,0.00001440095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001805075,0.00002056066,0.0001387761,0.0001150378,0.000006503406,0.00002222974,0.000007968018,0.00006665403,0.9970418,0.00009313465,0.0000554182,0.002251301],"study_design_scores_gemma":[0.00003277261,0.0003724954,0.008212009,0.00001419879,0.00003100762,0.0002061147,0.00004259855,0.0006385923,0.9841189,0.00009839339,0.006225967,0.000007079799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9619009,0.02112957,0.00825529,0.0004181607,0.0001893007,0.00009355499,0.001287917,0.0003673849,0.006357912],"genre_scores_gemma":[0.984507,0.007517437,0.005168517,0.0001366393,0.00005291213,0.00007741718,0.0007280572,0.0000449032,0.001767156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002005752,"threshold_uncertainty_score":0.006709933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105209037989468,"score_gpt":0.2023075056996925,"score_spread":0.1912554153197978,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}