{"id":"W2093846525","doi":"10.4161/cc.23511","title":"On the interaction mechanisms of a p53 peptide and nutlin with the MDM2 and MDMX proteins: A Brownian dynamics study","year":2013,"lang":"en","type":"article","venue":"Cell Cycle","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"MDMX; Mdm2; Allosteric regulation; Biology; Biophysics; Protein–protein interaction; Plasma protein binding; Cell biology; Biochemistry; Receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001408425,0.0001071981,0.0001349653,0.00003747432,0.00007511848,0.00002643551,0.00005583749,0.00003898708,0.00004866645],"category_scores_gemma":[0.00002637285,0.00005519489,0.00002195147,0.00009404707,0.00006939271,0.00004119688,0.00004094833,0.0002277255,0.00001237232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004583098,"about_ca_system_score_gemma":0.00002636151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004641695,"about_ca_topic_score_gemma":0.000376196,"domain_scores_codex":[0.9993671,0.00005858518,0.0001157458,0.0001781875,0.0001666405,0.000113788],"domain_scores_gemma":[0.9994563,0.00006315011,0.00008467375,0.0002945887,0.00005261931,0.00004864344],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003548078,0.005404565,0.003916497,0.000852989,0.001110954,0.0001936329,0.0448699,0.0006946972,0.883921,0.01054851,0.005256142,0.0396831],"study_design_scores_gemma":[0.03462201,0.04540793,0.07870093,0.002999823,0.002357513,0.0007971852,0.1871429,0.168841,0.4544745,0.0203251,0.002383515,0.001947565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927571,0.00006590777,0.001342922,0.001335789,0.00003115453,0.002071193,0.00000245701,0.00002045082,0.002373014],"genre_scores_gemma":[0.9990153,0.00001033238,0.0001844709,0.0002337869,0.00001526787,0.0001453941,0.000002225945,0.00002232271,0.0003708495],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4294465,"threshold_uncertainty_score":0.2250782,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005971991742603726,"score_gpt":0.2045957327226392,"score_spread":0.1986237409800354,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}