{"id":"W2093877605","doi":"10.1128/jvi.74.4.2052-2056.2000","title":"Herpes Simplex Virus ICP0 Mutants Are Hypersensitive to Interferon","year":2000,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Herpesvirus Infections and Treatments","field":"Medicine","cited_by":222,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Biology; Herpes simplex virus; Transactivation; Viral replication; Interferon; Virology; Virus; Gene; Molecular biology; Mutant; Transcription (linguistics); Gene product; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001241052,0.0001208612,0.000390972,0.0001714869,0.00005338574,0.000007945769,0.00004778749,0.000105431,0.002096091],"category_scores_gemma":[0.00005101617,0.00009006816,0.0001286133,0.0001221639,0.00004942845,0.00006143317,0.00001365864,0.0001921686,0.000506232],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000103453,"about_ca_system_score_gemma":0.00004789332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005020946,"about_ca_topic_score_gemma":0.00006307075,"domain_scores_codex":[0.9991425,0.00007208528,0.0003289497,0.000120033,0.000126073,0.0002104145],"domain_scores_gemma":[0.9993754,0.00005377796,0.0001294852,0.0001308028,0.0001080003,0.0002025152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003493112,0.001095692,0.003219462,0.000009789037,0.0006695295,0.003258532,0.0006437267,0.0001024515,0.00866691,0.00001983119,0.003015686,0.9758053],"study_design_scores_gemma":[0.005286493,0.007637249,0.1549679,0.0001638191,0.0004667109,0.007570898,0.0003772755,0.00006257246,0.01579264,0.0002543893,0.8072033,0.0002167652],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935758,0.0001031804,0.00009383457,0.001835599,0.0002167293,0.0001061111,0.00001058932,0.00001219697,0.004046034],"genre_scores_gemma":[0.99547,0.0001246802,0.0004263136,0.00300338,0.0002817342,0.000001918549,9.954214e-7,0.00001588957,0.0006750762],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9755885,"threshold_uncertainty_score":0.9988161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01556479220407251,"score_gpt":0.3008714438849264,"score_spread":0.2853066516808539,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}