{"id":"W2093879579","doi":"10.1007/s00213-007-0853-5","title":"Up-regulation of cPLA2 gene expression in astrocytes by all three conventional anti-bipolar drugs is drug-specific and enzyme-specific","year":2007,"lang":"en","type":"article","venue":"Psychopharmacology","topic":"Bipolar Disorder and Treatment","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Natural Science Foundation of China","keywords":"Valproic Acid; Carbamazepine; Phospholipase A2; In vivo; Arachidonic acid; Pharmacology; Gene expression; Chemistry; Anticonvulsant; Drug; Enzyme; Lithium (medication); Biology; Biochemistry; Endocrinology; Gene; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001135433,0.0003070397,0.0004286438,0.0003072318,0.0003109581,0.0003276083,0.0001406658,0.0003173983,0.002197882],"category_scores_gemma":[0.0001787774,0.0001876286,0.000463398,0.000287209,0.0003162719,0.0002789874,0.0002617058,0.0006324346,0.0004225147],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002958998,"about_ca_system_score_gemma":0.0002739773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001078899,"about_ca_topic_score_gemma":0.002263514,"domain_scores_codex":[0.9998301,0.00002406033,0.00001858864,0.00003122261,0.0000356243,0.00006029714],"domain_scores_gemma":[0.9998431,0.00002536475,0.00002774735,0.00002324641,0.000037847,0.00004260617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000513753,0.00002401218,0.0002493956,0.00005066536,0.00000877304,0.00009185219,0.00002424833,0.000009788042,0.997794,0.00006322235,0.00006680841,0.001103436],"study_design_scores_gemma":[0.00004851574,0.0006607054,0.03017483,0.00001106778,0.00003312565,0.0007311082,0.0001848538,0.0002237423,0.9654069,0.0001243246,0.002390738,0.000009980873],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9859539,0.002715197,0.003185538,0.0003040011,0.0001561148,0.00008839802,0.001346338,0.0001052088,0.006145312],"genre_scores_gemma":[0.9893926,0.001089164,0.003000096,0.0001813162,0.00006237902,0.000218604,0.0008122768,0.00003138472,0.00521226],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002197882,"threshold_uncertainty_score":0.00735265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01699798202518355,"score_gpt":0.3010116038323311,"score_spread":0.2840136218071475,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}