{"id":"W2093901546","doi":"10.1074/jbc.m113.546168","title":"Crystal Structures of the Human RNA Demethylase Alkbh5 Reveal Basis for Substrate Recognition","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"RNA modifications and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":195,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Wellcome Trust","keywords":"AlkB; Biology; RNA; N6-Methyladenosine; Demethylase; Biochemistry; RNA methylation; Methylation; DNA; Cell biology; Epigenetics; Gene; Methyltransferase; DNA repair","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001496113,0.0004534901,0.0003682837,0.00009466316,0.0002339495,0.0003113707,0.0004287538,0.000508158,0.001259109],"category_scores_gemma":[0.0002463204,0.0002043742,0.0002786631,0.0001360332,0.0001528377,0.0002973466,0.0002943663,0.0007383297,0.0003068162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005706675,"about_ca_system_score_gemma":0.0003203142,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001694245,"about_ca_topic_score_gemma":0.002153233,"domain_scores_codex":[0.9999077,0.00001264582,0.000006154617,0.0000226735,0.0000312962,0.00001944542],"domain_scores_gemma":[0.9999374,0.00001242485,0.00001393702,0.000003622035,0.00001021198,0.00002231251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001283355,0.0002297063,0.01017024,0.000687806,0.0001679859,0.001441092,0.000351671,0.006244355,0.9491339,0.003687335,0.004060611,0.02254177],"study_design_scores_gemma":[0.0004024836,0.0007920409,0.03963777,0.0001191959,0.0002984712,0.002508953,0.0007147377,0.06149401,0.8395732,0.002687737,0.05167389,0.00009761655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9822564,0.007922861,0.004896893,0.0004596988,0.00006936059,0.00005074917,0.0007733569,0.0001692392,0.00340152],"genre_scores_gemma":[0.9853516,0.00187968,0.00712824,0.0002225192,0.00001535816,0.00002206691,0.003393975,0.00001690835,0.001969659],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001694245,"threshold_uncertainty_score":0.004212141,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03326294579303263,"score_gpt":0.2773641602767651,"score_spread":0.2441012144837325,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}