{"id":"W2093947365","doi":"10.1016/j.bmc.2010.02.051","title":"Synthesis of 26-hydroxy-22-oxocholestanic frameworks from diosgenin and hecogenin and their in vitro antiproliferative and apoptotic activity on human cervical cancer CaSki cells","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Phytochemical Studies and Bioactivities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología","keywords":"Chemistry; Apoptosis; Cytotoxic T cell; Diosgenin; DNA fragmentation; HeLa; Cancer cell; Programmed cell death; Fragmentation (computing); Cell cycle; In vitro; Cytotoxicity; Cell culture; Cell growth; Cell; Cancer research; Apoptotic DNA fragmentation; Cancer; Cell biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001304901,0.0002977821,0.0004299742,0.000018545,0.0001023948,0.00001795445,0.000126342,0.0005049885,0.00004043613],"category_scores_gemma":[0.0001319463,0.0002354216,0.00004809851,0.00007216848,0.0005189908,0.000006657709,0.000188285,0.0006693947,2.822474e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002156041,"about_ca_system_score_gemma":0.00004443331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003820307,"about_ca_topic_score_gemma":0.0001167455,"domain_scores_codex":[0.9987859,0.0000385048,0.000218553,0.0005483133,0.000135863,0.0002728936],"domain_scores_gemma":[0.9993039,0.0001466336,0.0001192394,0.0002350707,0.00003548993,0.0001596408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002606396,0.0001201002,0.00195643,0.00009032735,0.0000880737,0.000003982677,0.0001484777,6.906888e-8,0.9937004,0.000001114497,0.00003053355,0.003599791],"study_design_scores_gemma":[0.0005366217,0.00009869809,0.009456696,0.00009920312,0.00004317603,0.00001279843,0.0004279621,0.00002195673,0.9889011,0.00005935522,0.00009791194,0.0002445557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978074,0.001475864,0.00001608895,0.0002428448,0.00005391764,0.0001459083,0.0001572736,0.00001036704,0.00009027805],"genre_scores_gemma":[0.9989103,0.0005035438,0.0000582577,0.0001113026,0.000323879,0.00003332933,0.00001413324,0.00002709412,0.00001813564],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007500266,"threshold_uncertainty_score":0.9600215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008208075815150035,"score_gpt":0.2460989613132481,"score_spread":0.2378908854980981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}