{"id":"W2093947365","doi":"10.1016/j.bmc.2010.02.051","title":"Synthesis of 26-hydroxy-22-oxocholestanic frameworks from diosgenin and hecogenin and their in vitro antiproliferative and apoptotic activity on human cervical cancer CaSki cells","year":2010,"lang":"en","type":"article","venue":"Bioorganic & Medicinal Chemistry","topic":"Phytochemical Studies and Bioactivities","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada; Consejo Nacional de Ciencia y Tecnología","keywords":"Chemistry; Apoptosis; Cytotoxic T cell; Diosgenin; DNA fragmentation; HeLa; Cancer cell; Programmed cell death; Fragmentation (computing); Cell cycle; In vitro; Cytotoxicity; Cell culture; Cell growth; Cell; Cancer research; Apoptotic DNA fragmentation; Cancer; Cell biology; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007493457,0.0003265653,0.0001323781,0.0003049271,0.0001290417,0.0001115219,0.0002173754,0.000123786,0.00181834],"category_scores_gemma":[0.00005104673,0.00007704921,0.000145657,0.0002582161,0.000118863,0.0001887605,0.0001662195,0.0001835891,0.0002469137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002331125,"about_ca_system_score_gemma":0.0002271352,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000757325,"about_ca_topic_score_gemma":0.002224751,"domain_scores_codex":[0.9999691,0.000003339924,0.000001773279,0.000005355417,0.000005626373,0.00001481094],"domain_scores_gemma":[0.9999784,0.000001791842,0.000005309099,0.000002141109,0.000002797453,0.000009591778],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003034367,0.000114331,0.0002039812,0.00018266,0.0000167539,0.0003334638,0.00008125472,0.00148072,0.9760049,0.001458489,0.0002784279,0.01954155],"study_design_scores_gemma":[0.00005212039,0.0009287898,0.00237317,0.00001280552,0.00002217488,0.0001692816,0.00005023543,0.0006605688,0.9836813,0.0003635071,0.01166748,0.00001863279],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9722477,0.003396396,0.007879648,0.0001679409,0.00007389122,0.0001849007,0.001197363,0.0001158474,0.01473635],"genre_scores_gemma":[0.9924691,0.001297384,0.002355082,0.00004274389,0.000008179595,0.00002874902,0.0003910064,0.00001054576,0.003397227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00181834,"threshold_uncertainty_score":0.006082892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008208075815150035,"score_gpt":0.2460989613132481,"score_spread":0.2378908854980981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}