{"id":"W2093984973","doi":"10.1038/ncb1865","title":"RAD18 transmits DNA damage signalling to elicit homologous recombination repair","year":2009,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":312,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; National Institutes of Health; Mayo Clinic","keywords":"Homologous recombination; DNA repair; Cell biology; DNA damage; Biology; Homology directed repair; DNA ligase; Non-homologous end joining; G2-M DNA damage checkpoint; DNA; Recombinase; Homologous chromosome; Genome instability; Genetics; Cell cycle checkpoint; Cell cycle; Nucleotide excision repair; Recombination; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003691808,0.0005324818,0.000342984,0.0004791716,0.000239593,0.0008271111,0.0003007849,0.000881426,0.006095499],"category_scores_gemma":[0.0003653346,0.0003874084,0.0004124196,0.0001755372,0.0002840531,0.000469481,0.0007762091,0.00133137,0.002127848],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005139477,"about_ca_system_score_gemma":0.00021418,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001202075,"about_ca_topic_score_gemma":0.0002743035,"domain_scores_codex":[0.999707,0.00004232948,0.00002009396,0.00004008749,0.00006492907,0.0001253682],"domain_scores_gemma":[0.9996684,0.00008259057,0.00007377561,0.00004980077,0.00002329578,0.0001022879],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002446704,0.00002549161,0.0001711234,0.000052532,0.000004277312,0.0001197266,0.00001213256,0.00007637451,0.99664,0.0005419665,0.0001618879,0.001949892],"study_design_scores_gemma":[0.0000509382,0.000221091,0.002437127,0.00001471696,0.00001402381,0.0003505395,0.00004538854,0.0007742367,0.991396,0.0003625058,0.004324562,0.000008878644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.981127,0.003020762,0.006547567,0.0007389527,0.0002996041,0.0000602429,0.0007084683,0.0003871036,0.00711031],"genre_scores_gemma":[0.9845198,0.001438157,0.003222218,0.000236726,0.00006990204,0.00003798797,0.0005647219,0.00008742623,0.009823025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006095499,"threshold_uncertainty_score":0.02039146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004656543842146198,"score_gpt":0.242047964246058,"score_spread":0.2373914204039118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}