{"id":"W2093984973","doi":"10.1038/ncb1865","title":"RAD18 transmits DNA damage signalling to elicit homologous recombination repair","year":2009,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":312,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"National Cancer Institute; National Institutes of Health; Mayo Clinic","keywords":"Homologous recombination; DNA repair; Cell biology; DNA damage; Biology; Homology directed repair; DNA ligase; Non-homologous end joining; G2-M DNA damage checkpoint; DNA; Recombinase; Homologous chromosome; Genome instability; Genetics; Cell cycle checkpoint; Cell cycle; Nucleotide excision repair; Recombination; Cell; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003320409,0.000250862,0.0002379965,0.000116676,0.00008547542,0.0000128114,0.0003444442,0.001133373,0.00004340996],"category_scores_gemma":[0.0001146343,0.0002398564,0.0001844171,0.0001901268,0.0000341718,0.000004093071,0.00005314752,0.0004012482,0.0000545312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002995099,"about_ca_system_score_gemma":0.00004846235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003280943,"about_ca_topic_score_gemma":0.00001167849,"domain_scores_codex":[0.9983612,0.0001552885,0.0002635712,0.0007008062,0.00009329774,0.0004258145],"domain_scores_gemma":[0.9992015,0.00002500726,0.00008231794,0.0004318228,0.0001252326,0.0001341551],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009873341,0.000102776,0.00004756831,0.000008292612,0.00002074907,0.00001274023,0.00003761354,0.00004747621,0.9906159,0.0007091332,0.002607794,0.005691198],"study_design_scores_gemma":[0.0005251819,0.001640127,0.0004081108,0.000008478205,0.00002054033,0.00001551572,0.00001415966,0.00007640316,0.9337089,0.001472589,0.06180809,0.0003018901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850485,0.001362134,0.003159788,0.0007876219,0.0005720761,0.0004293511,0.00001951977,0.0001561967,0.008464788],"genre_scores_gemma":[0.9882571,0.0000980273,0.005610407,0.003881464,0.0002616891,0.00001708685,0.000303064,0.00002607123,0.001545091],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0592003,"threshold_uncertainty_score":0.978106,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004656543842146198,"score_gpt":0.242047964246058,"score_spread":0.2373914204039118,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}