{"id":"W2094030442","doi":"10.1074/jbc.m114.616656","title":"Impaired Association of Retinal Degeneration-3 with Guanylate Cyclase-1 and Guanylate Cyclase-activating Protein-1 Leads to Leber Congenital Amaurosis-1","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; National Institutes of Health","keywords":"GUCY2D; Guanylate cyclase; GUCY1A3; Endoplasmic reticulum; Visual phototransduction; Biology; Retinal; Cell biology; Guanylate cyclase 2C; Genetics; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004859419,0.0001897717,0.0002874464,0.00002681497,0.00007348399,0.00003323313,0.0001406141,0.0002421839,0.0000272404],"category_scores_gemma":[0.0006861625,0.0001357914,0.00009386743,0.00009409288,0.00007993773,0.00001164057,0.00006754031,0.0001731782,0.000001246472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003604785,"about_ca_system_score_gemma":0.00007852838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002472216,"about_ca_topic_score_gemma":0.000002801755,"domain_scores_codex":[0.9987668,0.00007431461,0.0004694298,0.0002376596,0.00022235,0.0002294083],"domain_scores_gemma":[0.9988414,0.00004148887,0.000562387,0.0001154881,0.0002960578,0.0001431764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005190365,0.00004801848,0.0693647,0.00002682012,0.00005844571,0.000002867677,0.00002409442,0.00003937597,0.9289984,0.000004573719,0.000209329,0.0007043459],"study_design_scores_gemma":[0.0008817753,0.000857648,0.02483801,0.00006037033,0.00002207849,0.00004481194,0.00006382792,0.00003219386,0.9716991,0.00004375593,0.001237965,0.0002185049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997908,0.0001283785,0.0007173273,0.0003242237,0.00002913942,0.0001181861,0.00000740708,0.000006180408,0.0007611442],"genre_scores_gemma":[0.9958782,0.00004411211,0.003363169,0.000104222,0.0001881381,0.000007566946,0.00003060255,0.00001264549,0.0003714063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04452668,"threshold_uncertainty_score":0.5537413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008268383795018317,"score_gpt":0.2175060033039661,"score_spread":0.2092376195089478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}