{"id":"W2094030442","doi":"10.1074/jbc.m114.616656","title":"Impaired Association of Retinal Degeneration-3 with Guanylate Cyclase-1 and Guanylate Cyclase-activating Protein-1 Leads to Leber Congenital Amaurosis-1","year":2014,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Eye Institute; National Institutes of Health","keywords":"GUCY2D; Guanylate cyclase; GUCY1A3; Endoplasmic reticulum; Visual phototransduction; Biology; Retinal; Cell biology; Guanylate cyclase 2C; Genetics; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001863071,0.0005637363,0.0003236842,0.0003616426,0.0003067591,0.0002459335,0.0003126194,0.0004301389,0.002026075],"category_scores_gemma":[0.00036203,0.0001964608,0.0002462244,0.000206405,0.0002396958,0.0001118546,0.0005479977,0.0004008768,0.0006302182],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000518173,"about_ca_system_score_gemma":0.0002603458,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001540354,"about_ca_topic_score_gemma":0.001509432,"domain_scores_codex":[0.9997097,0.00006520413,0.00003747799,0.00005833935,0.00008132264,0.00004809667],"domain_scores_gemma":[0.9997725,0.0000416783,0.00009500617,0.00001595064,0.00001107474,0.00006380804],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001807498,0.00005022694,0.002321657,0.00004310917,0.00001823103,0.0008368838,0.00003647166,0.00009610057,0.9949063,0.0001516362,0.0001416237,0.00121699],"study_design_scores_gemma":[0.0001323612,0.0006277428,0.1366012,0.00005009494,0.0001381012,0.01703015,0.0001638041,0.005156153,0.8307132,0.0004561719,0.008897575,0.00003337284],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967089,0.000851698,0.001279614,0.00007788595,0.00002283577,0.00001544606,0.0002648634,0.0001133757,0.0006653472],"genre_scores_gemma":[0.9974953,0.0002472731,0.0007579057,0.00003649679,0.000005924807,0.00001922585,0.0003281004,0.00002028553,0.001089415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002026075,"threshold_uncertainty_score":0.006777942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008268383795018317,"score_gpt":0.2175060033039661,"score_spread":0.2092376195089478,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}