{"id":"W2094074562","doi":"10.1038/ng.683","title":"Mutations in WDR62, encoding a centrosome-associated protein, cause microcephaly with simplified gyri and abnormal cortical architecture","year":2010,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":286,"is_retracted":false,"has_abstract":false,"ca_institutions":"Health Sciences Centre; Alberta Children's Hospital; University of Alberta Hospital; University of Calgary","funders":"Fogarty International Center; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Howard Hughes Medical Institute; U.S. Public Health Service; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Human Genome Research Institute","keywords":"Microcephaly; Biology; Gene; Genetics; Locus (genetics); Phenotype; Cerebral cortex; Cell biology; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001219887,0.001580101,0.0004163119,0.001213616,0.0004922354,0.0002875265,0.0003290758,0.0007745598,0.00107527],"category_scores_gemma":[0.0006981745,0.0002971814,0.000320221,0.0006245461,0.001079706,0.0002073008,0.0005469535,0.0005604409,0.0003468471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004935808,"about_ca_system_score_gemma":0.0003046574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002567043,"about_ca_topic_score_gemma":0.004650437,"domain_scores_codex":[0.9998069,0.00002594965,0.00002482287,0.0000373154,0.0000830319,0.00002193406],"domain_scores_gemma":[0.9994739,0.0001636982,0.0002102407,0.00002765657,0.00002314847,0.0001013687],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001597092,0.0002789893,0.01743218,0.0003126553,0.0004105186,0.2024388,0.0007915767,0.002704715,0.7437024,0.002536688,0.003006818,0.02478758],"study_design_scores_gemma":[0.0008427687,0.001251197,0.2886082,0.0001323751,0.0007675294,0.3398534,0.0008235496,0.01278233,0.3383584,0.003971966,0.01236608,0.0002422811],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944174,0.0004932603,0.002169028,0.0002699108,0.00006703175,0.00005628046,0.000520642,0.000225425,0.001781146],"genre_scores_gemma":[0.996048,0.0003310583,0.001885784,0.00006004614,0.00003587109,0.00002468768,0.0002705228,0.0000408654,0.001303194],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002567043,"threshold_uncertainty_score":0.005104244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003636538149422772,"score_gpt":0.228613177115215,"score_spread":0.2249766389657922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}