{"id":"W2094118633","doi":"10.1007/s00280-004-0836-8","title":"Population pharmacokinetic analysis of 17-(allylamino)-17-demethoxygeldanamycin (17AAG) in adult patients with advanced malignancies","year":2004,"lang":"en","type":"article","venue":"Cancer Chemotherapy and Pharmacology","topic":"Cancer therapeutics and mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre","funders":"National Center for Research Resources; National Cancer Institute; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health","keywords":"Pharmacokinetics; NONMEM; Population; Medicine; Population pharmacokinetics; Pharmacology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005195987,0.000244428,0.0005936765,0.0002085796,0.0001554831,0.0004144038,0.0001358438,0.0003240788,0.0008823003],"category_scores_gemma":[0.001721615,0.0002050865,0.0003096218,0.0002833591,0.0001738544,0.0003236792,0.0001631513,0.0006359905,0.0002010929],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003401124,"about_ca_system_score_gemma":0.0003582571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009067929,"about_ca_topic_score_gemma":0.0006466789,"domain_scores_codex":[0.999608,0.0001598333,0.00001933763,0.00009297876,0.00007731865,0.00004253992],"domain_scores_gemma":[0.9992728,0.000311974,0.000156654,0.00008035815,0.00006836853,0.0001098487],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02969325,0.0008161771,0.8682487,0.00006104448,0.0008521468,0.000533001,0.0004627385,0.005833561,0.03926008,0.0003631373,0.001065061,0.05281116],"study_design_scores_gemma":[0.0005516608,0.01669024,0.9542382,0.000007217795,0.0004971891,0.002244948,0.0002113247,0.01322216,0.009549619,0.0002947305,0.002452893,0.0000397709],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985301,0.0001512551,0.0008002692,0.00003000264,0.000003349078,0.00001240886,0.0001760424,0.00003182333,0.0002647192],"genre_scores_gemma":[0.9990394,0.00007203285,0.0003283702,0.00003662635,0.000009291147,0.0000170303,0.0002554685,0.000008459863,0.0002334811],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009067929,"threshold_uncertainty_score":0.002951562,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007054605613093194,"score_gpt":0.2841659373518015,"score_spread":0.2771113317387083,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}