{"id":"W2094174868","doi":"10.1021/bi015611y","title":"Mutagenesis Identifies Amino Acid Residues in Extracellular Loops and within the Barrel Lumen That Determine Voltage Gating of Porin from <i>Haemophilus influenzae</i> Type b","year":2001,"lang":"en","type":"article","venue":"Biochemistry","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Porin; Gating; Mutant; Periplasmic space; Bacterial outer membrane; Biophysics; Chemistry; Biochemistry; Alanine; Amino acid; Biology; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164289,0.0004210448,0.0001945214,0.0001244287,0.0001426097,0.0002126648,0.0002554293,0.0003055548,0.0005481307],"category_scores_gemma":[0.0003470772,0.0001760815,0.0002617677,0.0001079929,0.0002906664,0.0001180691,0.0002178495,0.0003511573,0.0002503772],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000358654,"about_ca_system_score_gemma":0.0002520192,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009604056,"about_ca_topic_score_gemma":0.001335538,"domain_scores_codex":[0.9998294,0.00005308838,0.00002473047,0.00002520944,0.00004052694,0.00002710661],"domain_scores_gemma":[0.9997109,0.00007526232,0.0001212969,0.0000209499,0.00002579133,0.00004584501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003353212,0.00005652571,0.001324495,0.00003421112,0.00001474861,0.0002710754,0.0000411568,0.0004894309,0.9960495,0.000110731,0.00003158326,0.001241378],"study_design_scores_gemma":[0.00006965816,0.0006664203,0.02260721,0.00003273158,0.00008059039,0.001792244,0.0001199894,0.004377622,0.9689608,0.0001033938,0.001162413,0.00002683439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984474,0.00005494799,0.001069195,0.00002836714,0.000006027997,0.00002253818,0.00007006446,0.00001768037,0.0002837514],"genre_scores_gemma":[0.9980571,0.00008127217,0.001486668,0.00002883579,0.000003984248,0.00001074711,0.0001351621,0.00001027247,0.0001861281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009604056,"threshold_uncertainty_score":0.00260222,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01301405013395611,"score_gpt":0.2262521057105585,"score_spread":0.2132380555766024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}