{"id":"W2094214456","doi":"10.1021/bi201014b","title":"Permanent Inhibition of Viral Entry by Covalent Entrapment of HIV gp41 on the Virus Surface","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Hospital; McGill University Health Centre; Royal Victoria Regional Health Centre","funders":"","keywords":"Gp41; Heptad repeat; Viral entry; Viral envelope; Trimer; Protein subunit; Chemistry; Lipid bilayer fusion; Biophysics; Conformational change; Entry inhibitor; Transmembrane protein; Covalent bond; Virus; Cell biology; Biochemistry; Membrane; Biology; Virology; Peptide sequence; Viral replication; Glycoprotein; Dimer; Receptor; Epitope","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001254629,0.0003178495,0.0001629505,0.00009095995,0.0001537142,0.0002985994,0.0003024857,0.0002284631,0.0008557539],"category_scores_gemma":[0.0001318012,0.0001360095,0.0001692846,0.00005975757,0.0003133484,0.0002136672,0.0002609743,0.0005294051,0.0002113527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001998811,"about_ca_system_score_gemma":0.0001589001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003108991,"about_ca_topic_score_gemma":0.0004623269,"domain_scores_codex":[0.9998924,0.00001328495,0.000005115414,0.00001940917,0.00003336569,0.00003640463],"domain_scores_gemma":[0.999931,0.00001706674,0.0000200392,0.00001560436,0.000005435371,0.00001085093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005747837,0.00003421047,0.0001202926,0.000021612,0.00000535179,0.00002519959,0.0000109605,0.00009202598,0.9977912,0.0002474502,0.00001963711,0.001574605],"study_design_scores_gemma":[0.000006774772,0.0004250751,0.0007114873,0.000002827713,0.00001004738,0.00006167927,0.000006830226,0.000339306,0.9974977,0.00002972593,0.0009065354,0.000002014334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953604,0.0008914158,0.001932265,0.00004406619,0.00001819274,0.00002146893,0.00003067158,0.00003342527,0.001668106],"genre_scores_gemma":[0.9972737,0.0004913182,0.0008436203,0.00002879739,0.00001051955,0.00001126744,0.00003995066,0.000006691219,0.001294176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008557539,"threshold_uncertainty_score":0.002862751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570813279027242,"score_gpt":0.2259855123562916,"score_spread":0.2102773795660191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}