{"id":"W2094219632","doi":"10.1007/s40124-014-0069-1","title":"Gene Therapy for SCID","year":2014,"lang":"en","type":"article","venue":"Current Pediatrics Reports","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Adenosine deaminase deficiency; Genetic enhancement; Severe combined immunodeficiency; Medicine; Insertional mutagenesis; Immune system; Stem cell; Clinical trial; Hematopoietic stem cell; CRISPR; Viral vector; Haematopoiesis; Immunology; Bone marrow; Gene; Biology; Genetics; Internal medicine; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004690467,0.0004856953,0.0003647632,0.001207146,0.0006762832,0.0006728226,0.0004793189,0.0007427559,0.006769652],"category_scores_gemma":[0.0002660529,0.0001269197,0.0006517405,0.0005518129,0.0008342572,0.0004768017,0.0004485631,0.00113174,0.001221272],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006288592,"about_ca_system_score_gemma":0.0009548804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005936403,"about_ca_topic_score_gemma":0.0008448642,"domain_scores_codex":[0.9997824,0.00003081231,0.00001651006,0.00003835004,0.00009236479,0.00003953369],"domain_scores_gemma":[0.9998896,0.0000172765,0.00003300107,0.00002070955,0.00001525977,0.00002414753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001274996,0.0008868249,0.00157099,0.001501914,0.0001639069,0.001778854,0.0002418394,0.0006500989,0.7451457,0.03066845,0.0139669,0.2021496],"study_design_scores_gemma":[0.0003451397,0.00389069,0.006602174,0.0005506118,0.0002763224,0.01104837,0.0001736184,0.001393121,0.7026189,0.006372296,0.2666768,0.00005198881],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.5613206,0.1415569,0.07056864,0.01076792,0.004641482,0.001252871,0.004871596,0.003003064,0.202017],"genre_scores_gemma":[0.8514768,0.05756047,0.0204384,0.002682039,0.0007949706,0.0008628986,0.003516524,0.0001754196,0.06249254],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.006769652,"threshold_uncertainty_score":0.02264678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03142386142020632,"score_gpt":0.3408306807488551,"score_spread":0.3094068193286488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}