{"id":"W2094219632","doi":"10.1007/s40124-014-0069-1","title":"Gene Therapy for SCID","year":2014,"lang":"en","type":"article","venue":"Current Pediatrics Reports","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Adenosine deaminase deficiency; Genetic enhancement; Severe combined immunodeficiency; Medicine; Insertional mutagenesis; Immune system; Stem cell; Clinical trial; Hematopoietic stem cell; CRISPR; Viral vector; Haematopoiesis; Immunology; Bone marrow; Gene; Biology; Genetics; Internal medicine; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008312897,0.0001733334,0.0001508587,0.00009278606,0.000117596,0.00003975327,0.000183461,0.0001112802,0.00002060673],"category_scores_gemma":[0.0002653031,0.0001614581,0.0001606045,0.0001532609,0.00004686254,0.000003448782,0.00007417558,0.00009878832,0.000009077161],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001638911,"about_ca_system_score_gemma":0.0001909949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001585907,"about_ca_topic_score_gemma":0.000005324868,"domain_scores_codex":[0.9984483,0.00005871199,0.0003127376,0.0005186492,0.0002807816,0.0003808597],"domain_scores_gemma":[0.9987626,0.00002546598,0.0001667093,0.0006534638,0.0002391612,0.0001525624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00150036,0.0005481866,0.05574022,0.0001252346,0.00007306338,0.00001075857,0.0000506133,0.0001887453,0.5295106,0.00004047687,0.05745469,0.3547571],"study_design_scores_gemma":[0.001023537,0.002490816,0.001532047,0.000003512698,0.0000204359,0.00004354159,0.000003202461,0.00009781421,0.4790279,0.0006943365,0.5146427,0.000420088],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9828436,0.0101959,0.004904537,0.00008465505,0.001172754,0.0005393011,0.00001476982,0.00002792803,0.0002164913],"genre_scores_gemma":[0.9905611,0.004505197,0.0005476936,0.000119389,0.003283376,0.0001702484,0.0004055484,0.00005595162,0.0003514863],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.457188,"threshold_uncertainty_score":0.658407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03142386142020632,"score_gpt":0.3408306807488551,"score_spread":0.3094068193286488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}