{"id":"W2094255857","doi":"10.1371/journal.pntd.0000464","title":"A Novel Biological Activity of Praziquantel Requiring Voltage-Operated Ca2+ Channel β Subunits: Subversion of Flatworm Regenerative Polarity","year":2009,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Planarian Biology and Electrostimulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of General Medical Sciences; University of Minnesota; National Institutes of Health; National Science Foundation","keywords":"Flatworm; Biology; Praziquantel; Schistosoma mansoni; Gene knockdown; In vivo; Cell biology; RNA interference; Drug discovery; Pharmacology; Immunology; Bioinformatics; Genetics; Cell culture","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000703759,0.0002746078,0.0001451717,0.000128329,0.00009212258,0.0001974356,0.000167814,0.0002111734,0.0006831305],"category_scores_gemma":[0.00007517964,0.00007082044,0.0001436271,0.00006217726,0.0001952913,0.0001280455,0.0001248131,0.0003173714,0.0001253205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001668662,"about_ca_system_score_gemma":0.0001492583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004198109,"about_ca_topic_score_gemma":0.0007840303,"domain_scores_codex":[0.9999517,0.000004141266,0.000003315956,0.00001150974,0.00001648886,0.00001280734],"domain_scores_gemma":[0.9999452,0.000008872528,0.00001658604,0.000005852733,0.00001156297,0.00001194034],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000162854,0.000003135683,0.00004798941,0.00001697195,9.489776e-7,0.00001938892,0.000001851052,0.000008946226,0.9994149,0.0000248867,0.000006620665,0.0004380528],"study_design_scores_gemma":[0.00001466063,0.0002486347,0.004317644,0.00000390375,0.00001282495,0.0003159295,0.00001270056,0.0003435848,0.9931254,0.00003476417,0.001567156,0.000002800703],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900051,0.002341579,0.004754181,0.0001678602,0.00003742721,0.00006714237,0.0002659691,0.000104207,0.002256591],"genre_scores_gemma":[0.995136,0.000984084,0.001923258,0.00007163396,0.000008165861,0.00002573373,0.0001878257,0.00000866211,0.00165467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006831305,"threshold_uncertainty_score":0.002285302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02466237554114175,"score_gpt":0.2516208819841476,"score_spread":0.2269585064430059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}