{"id":"W2094255857","doi":"10.1371/journal.pntd.0000464","title":"A Novel Biological Activity of Praziquantel Requiring Voltage-Operated Ca2+ Channel β Subunits: Subversion of Flatworm Regenerative Polarity","year":2009,"lang":"en","type":"article","venue":"PLoS neglected tropical diseases","topic":"Planarian Biology and Electrostimulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; National Institute of General Medical Sciences; University of Minnesota; National Institutes of Health; National Science Foundation","keywords":"Flatworm; Biology; Praziquantel; Schistosoma mansoni; Gene knockdown; In vivo; Cell biology; RNA interference; Drug discovery; Pharmacology; Immunology; Bioinformatics; Genetics; Cell culture","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00001028693,0.0001976152,0.0003213854,0.00006971423,0.000104409,0.000007433219,0.0001562582,0.0003158391,0.0000139804],"category_scores_gemma":[0.0006351421,0.0001648595,0.0001107787,0.0002563737,0.0001679042,0.00001456108,0.00005141025,0.0001612173,0.000001268969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000237633,"about_ca_system_score_gemma":0.0001047413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002606358,"about_ca_topic_score_gemma":0.00002445638,"domain_scores_codex":[0.9988097,0.0001486461,0.0002619147,0.0003701435,0.0001248488,0.0002847809],"domain_scores_gemma":[0.9992098,0.00005515218,0.0001551142,0.0002264298,0.0002346991,0.0001188246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002132085,0.0008592161,0.006964751,0.00001745961,0.0001023817,0.000003207024,0.00001909628,0.00008095348,0.9892197,0.0002381413,0.0001231632,0.0002398374],"study_design_scores_gemma":[0.000660493,0.001264029,0.4773617,0.00002750906,0.00004721059,0.00000377271,0.00000467539,0.001077731,0.5192965,0.0001105049,0.00001601902,0.0001298595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992312,0.000469542,0.006271832,0.0003552875,0.00003227854,0.0002321785,0.0002535585,0.00003043852,0.00004288902],"genre_scores_gemma":[0.9987596,0.000119871,0.0001145043,0.0002136573,0.0001004058,0.000005982952,0.0006583832,0.000008432819,0.00001914723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.470397,"threshold_uncertainty_score":0.6722777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02466237554114175,"score_gpt":0.2516208819841476,"score_spread":0.2269585064430059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}