{"id":"W2094260855","doi":"10.1371/journal.pone.0116773","title":"Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands","year":2015,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; Alberta Innovates; Gilead Sciences; GlaxoSmithKline; AstraZeneca","keywords":"Glucocorticoid; Glucocorticoid receptor; Endocrinology; Internal medicine; Tumor necrosis factor alpha; Reporter gene; Agonist; Cytokine; Kinase; Biology; Chemistry; Receptor; Gene expression; Medicine; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000187646,0.0004095606,0.000423471,0.000164607,0.0001108567,0.0002847429,0.0002048199,0.0002235334,0.00118051],"category_scores_gemma":[0.0001176877,0.000102423,0.0003465488,0.0001877031,0.0001755761,0.0001779052,0.0001162848,0.0005477243,0.0002579142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002490947,"about_ca_system_score_gemma":0.0002349068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008279182,"about_ca_topic_score_gemma":0.00159986,"domain_scores_codex":[0.9998368,0.00003394517,0.00001804381,0.00003459811,0.00003826201,0.00003842242],"domain_scores_gemma":[0.9999063,0.00001711225,0.00002311235,0.00001361794,0.00001179524,0.00002800002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006049098,0.00009382742,0.0001010621,0.00008446446,0.0000106242,0.00003076361,0.0000127823,0.00004650929,0.9972223,0.00003117651,0.00005886939,0.00170278],"study_design_scores_gemma":[0.00003912283,0.001236849,0.002403475,0.000006350665,0.00002242974,0.0001201531,0.00001730716,0.000243692,0.9936795,0.000009436221,0.002217425,0.000004324858],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9799691,0.01559484,0.001667882,0.0001827792,0.0001465617,0.00006715325,0.0007838611,0.00009253169,0.001495262],"genre_scores_gemma":[0.9870338,0.006376985,0.002407938,0.00007339182,0.00004172649,0.00007544134,0.00132311,0.00002490871,0.002642714],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00118051,"threshold_uncertainty_score":0.003949165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03061787523035244,"score_gpt":0.2553646317066049,"score_spread":0.2247467564762524,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}