{"id":"W2094263795","doi":"10.1021/bi051634r","title":"Glycogen Synthase Kinase 3β Phosphorylates Alzheimer's Disease-Specific Ser<sup>396</sup> of Microtubule-Associated Protein Tau by a Sequential Mechanism","year":2006,"lang":"en","type":"article","venue":"Biochemistry","topic":"Wnt/β-catenin signaling in development and cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Phosphorylation; GSK-3; Biology; GSK3B; Kinase; Phosphorylation cascade; Microtubule-associated protein; Protein phosphorylation; Hyperphosphorylation; Cell biology; Microtubule; Protein kinase A","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001565704,0.0004410793,0.0001775857,0.0002142795,0.0001623421,0.000231126,0.0001327752,0.000163564,0.002111226],"category_scores_gemma":[0.0001210951,0.0001579144,0.0004929394,0.000112234,0.0001776516,0.0001431108,0.0002067747,0.0003661964,0.001141559],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002984611,"about_ca_system_score_gemma":0.0002504651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006472684,"about_ca_topic_score_gemma":0.0009608292,"domain_scores_codex":[0.9999356,0.00001167259,0.000007355374,0.000009816405,0.00001531413,0.00002021514],"domain_scores_gemma":[0.9999558,0.000004651944,0.00001643185,0.000005074823,0.000004205896,0.00001386829],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003974143,0.00008802305,0.0007520063,0.00008360483,0.0000228946,0.0002324566,0.00002773323,0.00005716097,0.9960529,0.0001641474,0.0001739892,0.001947717],"study_design_scores_gemma":[0.0001586158,0.0006228234,0.02836954,0.00002710481,0.00005782089,0.001250245,0.0000810694,0.001400906,0.9633072,0.0005869702,0.004120874,0.00001683165],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958467,0.001386539,0.0006472879,0.0001540548,0.0000460363,0.0000181205,0.0001545327,0.00003388481,0.001712981],"genre_scores_gemma":[0.9914038,0.001844714,0.001178775,0.0001683145,0.00003419132,0.00004484381,0.001091304,0.00001578253,0.004218199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002111226,"threshold_uncertainty_score":0.007062733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008909248978321514,"score_gpt":0.2082341604959698,"score_spread":0.1993249115176483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}