{"id":"W2094309691","doi":"10.1038/ncomms5980","title":"Kainate receptor activation induces glycine receptor endocytosis through PKC deSUMOylation","year":2014,"lang":"en","type":"article","venue":"Nature Communications","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"National Key Research and Development Program of China; Major Research Plan; National Natural Science Foundation of China","keywords":"Glycine receptor; SUMO protein; Kainate receptor; Cell biology; Endocytosis; Protein kinase C; Biology; Excitatory postsynaptic potential; Inhibitory postsynaptic potential; Receptor; NMDA receptor; Neuroscience; AMPA receptor; Biochemistry; Glycine; Kinase; Ubiquitin; Amino acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002910496,0.0001597211,0.000129241,0.00004822724,0.0003413119,0.00003892029,0.000673016,0.0004332579,0.00005247685],"category_scores_gemma":[0.0005851339,0.0001567395,0.00007450793,0.0002146094,0.00009509118,0.00002101184,0.0002549853,0.000502491,0.00005814578],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003391433,"about_ca_system_score_gemma":0.000060969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000193759,"about_ca_topic_score_gemma":0.00003598705,"domain_scores_codex":[0.9988945,0.0002923979,0.000219587,0.0002678259,0.0001378187,0.0001879161],"domain_scores_gemma":[0.9981397,0.00009640283,0.0001653916,0.001327196,0.0002164725,0.00005482556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000387562,0.00008671662,0.0003507604,0.00001181203,0.00003222221,1.202552e-8,0.0001578353,0.00000614203,0.9776362,0.009034678,0.0062546,0.006390299],"study_design_scores_gemma":[0.0002653519,0.00007922854,0.0006466522,0.00002543924,0.000008315077,8.026858e-7,0.0000429727,0.00003182805,0.605842,0.0002796576,0.3926378,0.0001399119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9613495,0.002219154,0.00322234,0.007573381,0.000359129,0.0006356995,0.00007033619,0.0001135246,0.02445696],"genre_scores_gemma":[0.9803478,0.0008954857,0.01538714,0.0009557385,0.0002923509,0.0001199644,0.001678102,0.00002742054,0.000295971],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3863832,"threshold_uncertainty_score":0.6391649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02605207142974279,"score_gpt":0.2965145037440199,"score_spread":0.2704624323142771,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}