{"id":"W2094312018","doi":"10.1124/mol.107.039511","title":"Effect of Cathepsin K Inhibitor Basicity on in Vivo Off-Target Activities","year":2007,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Cathepsin; Cathepsin B; Cathepsin O; In vivo; Chemistry; Cathepsin H; Cysteine protease; Biochemistry; Benzamide; Cathepsin L; Cathepsin A; Cysteine; Pharmacology; Enzyme; Enzyme inhibitor; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005967836,0.0005548515,0.0007264944,0.0002526156,0.0002235545,0.0004623016,0.0004654158,0.0004315492,0.003619602],"category_scores_gemma":[0.0008100114,0.0002355042,0.0003038314,0.0003452111,0.000588824,0.000376931,0.0002380442,0.001379124,0.0004171937],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004207759,"about_ca_system_score_gemma":0.0006975091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001513312,"about_ca_topic_score_gemma":0.00127252,"domain_scores_codex":[0.999549,0.0001460789,0.00003358321,0.00004791489,0.00005437189,0.0001690798],"domain_scores_gemma":[0.9992613,0.0003586551,0.00009731807,0.00008572129,0.0000568779,0.0001401047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01829193,0.0008754626,0.0003789963,0.0001054348,0.00005063651,0.0001890897,0.00006058911,0.0006289979,0.9741465,0.0003470636,0.0002946168,0.004630687],"study_design_scores_gemma":[0.0002094188,0.003337478,0.001134581,0.000004884021,0.00004019373,0.0001846056,0.00002003439,0.0008744017,0.9931249,0.00006134191,0.0009961217,0.00001198652],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966151,0.0009647895,0.0005564389,0.0000961757,0.00004655541,0.00002734238,0.00026436,0.00006151994,0.001367655],"genre_scores_gemma":[0.9968624,0.0005794388,0.0005464876,0.00004485375,0.00002953207,0.00002564058,0.000446579,0.0000337529,0.00143128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003619602,"threshold_uncertainty_score":0.0121088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003606749746180091,"score_gpt":0.27689324066056,"score_spread":0.2732864909143799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}