{"id":"W2094312018","doi":"10.1124/mol.107.039511","title":"Effect of Cathepsin K Inhibitor Basicity on in Vivo Off-Target Activities","year":2007,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Bone Metabolism and Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":false,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"","keywords":"Cathepsin; Cathepsin B; Cathepsin O; In vivo; Chemistry; Cathepsin H; Cysteine protease; Biochemistry; Benzamide; Cathepsin L; Cathepsin A; Cysteine; Pharmacology; Enzyme; Enzyme inhibitor; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005332336,0.0002007739,0.0002827155,0.0001339165,0.00002807619,0.00000439352,0.0001567723,0.00016025,0.00008748477],"category_scores_gemma":[0.00007116557,0.0001886786,0.0001383052,0.0001256592,0.0001320585,0.000003696561,0.00008801893,0.0001201289,0.000004446793],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001656984,"about_ca_system_score_gemma":0.00005480518,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002399925,"about_ca_topic_score_gemma":0.00001248977,"domain_scores_codex":[0.998656,0.000292769,0.0002383352,0.0003312546,0.000134906,0.0003467347],"domain_scores_gemma":[0.999504,0.00007250172,0.00008739581,0.000209129,0.00002716841,0.00009982388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001576672,0.0002585494,0.002285461,0.00004544513,0.00004649159,0.00007475105,0.00002421149,0.00009407685,0.9912565,0.00006480668,0.001767942,0.002505049],"study_design_scores_gemma":[0.001858982,0.000899402,0.001334669,0.00000766846,0.00004695039,0.000005222396,0.00001204153,0.00001544402,0.984042,0.00001993611,0.01159476,0.0001628485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953429,0.001601653,0.000368701,0.00005548946,0.0004066284,0.0002976758,0.00003923431,0.0000115907,0.001876178],"genre_scores_gemma":[0.9987182,0.000056769,0.00009562105,0.0007633705,0.0001844957,0.0000279696,0.00002358228,0.0000251564,0.0001048108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009826822,"threshold_uncertainty_score":0.7694092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003606749746180091,"score_gpt":0.27689324066056,"score_spread":0.2732864909143799,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}