{"id":"W2094421860","doi":"10.1073/pnas.0711894105","title":"CASY-1, an ortholog of calsyntenins/alcadeins, is essential for learning in <i>Caenorhabditis elegans</i>","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Institute of Genetics; National Center for Research Resources; Tokyo Women's Medical University; National Institutes of Health; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Ectodomain; Caenorhabditis elegans; Biology; Transmembrane protein; Mutant; Cell biology; Transmembrane domain; Genetic screen; Amyloid precursor protein; Genetics; Gene; Receptor; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006476822,0.00009117337,0.0001586253,0.0000957493,0.0001406911,0.000007375739,0.0005171252,0.0001324478,0.000004338176],"category_scores_gemma":[0.0002990943,0.00007409324,0.00008137309,0.000235225,0.0007364647,0.00002411617,0.00009686866,0.0001121121,1.7316e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007623825,"about_ca_system_score_gemma":0.00006102074,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002228971,"about_ca_topic_score_gemma":0.000001130514,"domain_scores_codex":[0.9988118,0.000009216336,0.0003150361,0.0002635487,0.0004407169,0.0001596429],"domain_scores_gemma":[0.9993479,0.00002069623,0.0003157255,0.00001272749,0.0002732986,0.00002967467],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002302409,0.00005633934,0.02535607,0.0000453561,0.000009805132,1.264833e-8,0.0005255106,0.0003783627,0.9723585,0.0007326346,0.0003891722,0.0001251854],"study_design_scores_gemma":[0.0002468523,0.0002009592,0.03374444,0.00002219976,0.000008957585,0.00002002033,0.0001672393,0.0004534002,0.9626382,0.001697376,0.0007122329,0.00008814631],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985444,0.0002190828,0.00005197603,0.0006389468,0.00002014281,0.00015101,0.00002613469,0.0000033998,0.0003449143],"genre_scores_gemma":[0.9962871,0.0001808427,0.003004035,0.0002407327,0.00009585168,0.000007916537,0.000001557367,0.000006493481,0.0001754756],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009720354,"threshold_uncertainty_score":0.3021435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0281463741622954,"score_gpt":0.2915920945612781,"score_spread":0.2634457203989827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}