{"id":"W2094421860","doi":"10.1073/pnas.0711894105","title":"CASY-1, an ortholog of calsyntenins/alcadeins, is essential for learning in <i>Caenorhabditis elegans</i>","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Institute of Genetics; National Center for Research Resources; Tokyo Women's Medical University; National Institutes of Health; Ministry of Education, Culture, Sports, Science and Technology","keywords":"Ectodomain; Caenorhabditis elegans; Biology; Transmembrane protein; Mutant; Cell biology; Transmembrane domain; Genetic screen; Amyloid precursor protein; Genetics; Gene; Receptor; Alzheimer's disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005345457,0.0008569281,0.0002255204,0.0003108214,0.0003911764,0.000365894,0.000374596,0.0003912941,0.0008751087],"category_scores_gemma":[0.0001386438,0.0002030971,0.0002062535,0.0001060788,0.0003514661,0.0001615443,0.0003853697,0.0005694942,0.0005677974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006417683,"about_ca_system_score_gemma":0.0004680431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003195238,"about_ca_topic_score_gemma":0.006112089,"domain_scores_codex":[0.9998728,0.000006523738,0.000011726,0.0000365218,0.00004657744,0.00002590621],"domain_scores_gemma":[0.9998118,0.00002516859,0.0000657573,0.00001171404,0.00001592014,0.00006955589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003832948,0.00001057967,0.0002350495,0.00002106993,0.000002309318,0.0001379312,0.00000925309,0.00007849323,0.9985299,0.00007140602,0.00005469347,0.0008109822],"study_design_scores_gemma":[0.00002500004,0.00007404252,0.01799295,0.0000163753,0.00001717089,0.0006139696,0.00004574261,0.003111776,0.9728366,0.00009451218,0.005156616,0.0000152849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924307,0.001031142,0.003218669,0.0001178572,0.00004452966,0.00002874193,0.001003133,0.0003793275,0.001745945],"genre_scores_gemma":[0.9907647,0.0003629562,0.002790492,0.0000518617,0.000007561988,0.00003643679,0.001142708,0.00007865462,0.004764486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003195238,"threshold_uncertainty_score":0.006353259,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0281463741622954,"score_gpt":0.2915920945612781,"score_spread":0.2634457203989827,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}