{"id":"W2094422744","doi":"10.1016/j.addr.2008.10.003","title":"Pharmacokinetics and pharmacogenomics in breast cancer chemotherapy","year":2008,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Princess Margaret Cancer Centre; Montreal Heart Institute","funders":"","keywords":"Pharmacogenomics; Breast cancer; Vinca; Medicine; Chemotherapy; Pharmacokinetics; Oncology; Docetaxel; Cancer; Vindesine; Pharmacology; Internal medicine; Cyclophosphamide; Vincristine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008894751,0.001217589,0.002403498,0.002172385,0.0002122457,0.00107198,0.0007608398,0.001220783,0.003371291],"category_scores_gemma":[0.001075053,0.0004649592,0.0006202509,0.002486544,0.0005422082,0.001417816,0.0005647598,0.001872041,0.002367503],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000663409,"about_ca_system_score_gemma":0.001148384,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009423309,"about_ca_topic_score_gemma":0.002098858,"domain_scores_codex":[0.9997309,0.00006672178,0.00003465883,0.00003967767,0.0001092797,0.00001871504],"domain_scores_gemma":[0.9994214,0.0002946985,0.000117053,0.00001948558,0.0001190772,0.0000284366],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001427907,0.0001510707,0.0001640739,0.01043438,0.0001215463,0.0002261725,0.00003145065,0.0009074457,0.003272119,0.002274599,0.0286114,0.9536629],"study_design_scores_gemma":[0.00009705558,0.0003473421,0.0012975,0.003102925,0.0004166487,0.002501274,0.0000363214,0.0007053379,0.002196029,0.002768561,0.9864937,0.0000373533],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001723262,0.9979528,0.0005203411,0.0003349242,0.0002041312,0.000007575414,0.00001518767,0.00001476091,0.0007779349],"genre_scores_gemma":[0.0007572079,0.9974126,0.0004459384,0.0002531039,0.0002614274,0.000008167312,0.00002015108,0.000002013507,0.0008393574],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003371291,"threshold_uncertainty_score":0.01127809,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0463623682451442,"score_gpt":0.3918706415607305,"score_spread":0.3455082733155863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}