{"id":"W2094431079","doi":"10.1158/1538-7445.am10-lb-100","title":"Abstract LB-100: Optimal modulation of DNA repair in CLL therapy","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Nilotinib; Imatinib; Cancer research; Chronic lymphocytic leukemia; Sensitization; Tyrosine kinase; DNA damage; Chlorambucil; ABL; DNA repair; Pharmacology; Chemistry; Leukemia; DNA; Medicine; Immunology; Chemotherapy; Biochemistry; Internal medicine; Receptor; Myeloid leukemia","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002221214,0.0003234491,0.0003532646,0.0005288356,0.0001653407,0.0005838628,0.000306002,0.0003592762,0.003107334],"category_scores_gemma":[0.0002000322,0.000138122,0.0001607223,0.0003392316,0.0002302612,0.0002200205,0.0003701702,0.0008879284,0.000816663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000504348,"about_ca_system_score_gemma":0.00044224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000883864,"about_ca_topic_score_gemma":0.001315918,"domain_scores_codex":[0.999856,0.0000373822,0.00001175168,0.00002197121,0.00003189507,0.00004092746],"domain_scores_gemma":[0.9999257,0.00001225601,0.00001271961,0.000006226488,0.00000913873,0.00003379494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00253426,0.0009373416,0.0005904007,0.0001958988,0.00002818615,0.00008954285,0.00004958385,0.001071818,0.9518917,0.0005938053,0.001627137,0.04039052],"study_design_scores_gemma":[0.0005821214,0.008194592,0.004864889,0.00007917442,0.0000842702,0.0007282667,0.00005946653,0.003101621,0.9576728,0.0002302962,0.02437143,0.00003113167],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.966555,0.0183636,0.003481171,0.0006676699,0.0001243125,0.0001551475,0.0009403568,0.0006219574,0.009090761],"genre_scores_gemma":[0.9925991,0.00229736,0.001699236,0.0001222495,0.00001872473,0.00007049274,0.0009596746,0.00003516014,0.002198093],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.003107334,"threshold_uncertainty_score":0.01039511,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09851134286018154,"score_gpt":0.451178262846086,"score_spread":0.3526669199859045,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}