{"id":"W2094455722","doi":"10.1371/journal.pone.0024806","title":"Virtual High-Throughput Screening Identifies Mycophenolic Acid as a Novel RNA Capping Inhibitor","year":2011,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Mycophenolic acid; High-throughput screening; Throughput; Virtual screening; Chemistry; RNA; Computational biology; Cell biology; Drug discovery; Biology; Computer science; Biochemistry; Medicine; Gene; Transplantation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004721466,0.001055698,0.002078837,0.0009722192,0.000355289,0.001338051,0.001216181,0.0007837718,0.001787262],"category_scores_gemma":[0.0006225182,0.0003210617,0.0009309599,0.001039659,0.0002113593,0.0005504831,0.0006014004,0.0005460714,0.0005904777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005149117,"about_ca_system_score_gemma":0.0006305126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009633491,"about_ca_topic_score_gemma":0.001420891,"domain_scores_codex":[0.9996582,0.00006306916,0.00001609283,0.00007056706,0.0001432176,0.00004882689],"domain_scores_gemma":[0.9998316,0.00005891011,0.00003304785,0.00001448038,0.00002844035,0.00003356142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.003991553,0.002592594,0.01235276,0.002964248,0.001324078,0.001972972,0.00009261743,0.163853,0.6335036,0.002661315,0.006804211,0.167887],"study_design_scores_gemma":[0.0007196164,0.005519972,0.006524907,0.00009932927,0.001849247,0.001659934,0.0001381292,0.5402269,0.4192531,0.001148114,0.02272711,0.000133649],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9414235,0.01660308,0.02356797,0.0005387767,0.0001064965,0.0004145594,0.0056407,0.002499355,0.009205533],"genre_scores_gemma":[0.9588552,0.006158229,0.02216983,0.0002618007,0.00002417499,0.0002096006,0.01005015,0.00008354394,0.00218744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002078837,"threshold_uncertainty_score":0.005979002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06202947845947328,"score_gpt":0.248674221380112,"score_spread":0.1866447429206387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}