{"id":"W2094485106","doi":"10.1186/1476-511x-10-182","title":"In vitro and in vivo plasmalogen replacement evaluations in rhizomelic chrondrodysplasia punctata and Pelizaeus-Merzbacher disease using PPI-1011, an ether lipid plasmalogen precursor","year":2011,"lang":"en","type":"article","venue":"Lipids in Health and Disease","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital; Phenomenome Discoveries (Canada)","funders":"Fondation de l'Hôpital de Montréal pour enfants; Children's Hospital Foundation; McGill University","keywords":"Plasmalogen; Peroxisomal disorder; Peroxisome; Endoplasmic reticulum; Biology; Biochemistry; Phospholipid; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002705145,0.000318005,0.0002805414,0.0002450088,0.0001644664,0.0002152745,0.0002363917,0.0004637475,0.001069395],"category_scores_gemma":[0.0001379097,0.0001191464,0.0002326019,0.0001864747,0.0002188434,0.0002388408,0.0001303677,0.0005859137,0.0003693193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002048617,"about_ca_system_score_gemma":0.0001281545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005384982,"about_ca_topic_score_gemma":0.0004369154,"domain_scores_codex":[0.9997963,0.0000578663,0.0000285791,0.00004158314,0.00004474905,0.00003090049],"domain_scores_gemma":[0.9997819,0.00006468658,0.00005344133,0.00003171927,0.00002128443,0.00004691584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003576045,0.000149591,0.0002939566,0.00002553588,0.000004566513,0.00008535785,0.00002991189,0.00007781325,0.9978718,0.00002642665,0.00001747801,0.001060002],"study_design_scores_gemma":[0.00005264818,0.004495426,0.003446324,0.000003150954,0.00003162235,0.0004556818,0.0000606518,0.0005172818,0.98983,0.00001678232,0.001085119,0.000005423688],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980657,0.0005735178,0.0005703279,0.00002791688,0.00001066791,0.00002730074,0.0001953817,0.00002942515,0.0004997108],"genre_scores_gemma":[0.9959902,0.0004793754,0.001236268,0.00002489002,0.000006514825,0.00005823381,0.0004577401,0.00001192528,0.001734783],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001069395,"threshold_uncertainty_score":0.003577471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03494351560809147,"score_gpt":0.3123307194647674,"score_spread":0.2773872038566759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}