{"id":"W2094497499","doi":"10.1139/o03-072","title":"Low concentration of guanidine hydrochloride induces the formation of an aggregation-prone state in α-urease","year":2004,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Guanidine; Chemistry; Urease; Fibril; Circular dichroism; Hydrochloride; Denaturation (fissile materials); Canavalia ensiformis; Crystallography; Biophysics; Protein quaternary structure; Protein tertiary structure; Congo red; Conformational isomerism; Protein aggregation; Native state; Protein secondary structure; Enzyme; Biochemistry; Organic chemistry; Nuclear chemistry; Molecule; Protein subunit","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001293286,0.00005487286,0.00008160088,0.0000106443,0.00002699342,0.000004759899,0.00005692039,0.00006550211,0.00001686411],"category_scores_gemma":[0.00002092207,0.00003836597,0.00001038909,0.00005766691,0.0001082422,0.0000868151,0.00001126524,0.000036841,6.80806e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001171987,"about_ca_system_score_gemma":0.00003136007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001050532,"about_ca_topic_score_gemma":0.00002116107,"domain_scores_codex":[0.9995763,0.00002225698,0.0001845661,0.0001031964,0.00003861732,0.00007500763],"domain_scores_gemma":[0.9996961,0.00001623376,0.000144336,0.00009176641,0.00003273526,0.00001882717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005930018,0.00002623638,0.00008675682,0.00005216672,7.963682e-7,2.493294e-7,0.0002916532,0.0001215947,0.9984576,0.00008706811,0.000001791241,0.0008148162],"study_design_scores_gemma":[0.0003733864,0.00008911359,0.0002359205,0.00001560544,0.000004162581,0.000002788322,0.0001190298,0.00004542709,0.9969572,0.002106037,0.000009894216,0.00004136349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99912,0.0002095506,0.0002590656,0.00003015966,0.0000616664,0.00006865183,0.00001890859,0.000005205751,0.00022681],"genre_scores_gemma":[0.9997227,0.00004425563,0.00009854678,0.00002013633,0.0000341104,0.000004042256,0.00006650362,0.000001687494,0.000008073263],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002018969,"threshold_uncertainty_score":0.1564519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006591314975890251,"score_gpt":0.2147920698069391,"score_spread":0.2082007548310489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}