{"id":"W2094501679","doi":"10.1016/j.atherosclerosis.2013.01.041","title":"Inhibition of sphingolipid synthesis improves dyslipidemia in the diet-induced hamster model of insulin resistance: Evidence for the role of sphingosine and sphinganine in hepatic VLDL-apoB100 overproduction","year":2013,"lang":"en","type":"article","venue":"Atherosclerosis","topic":"Diet, Metabolism, and Disease","field":"Medicine","cited_by":66,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Heart and Stroke Foundation of Canada","keywords":"Sphingolipid; Internal medicine; Insulin resistance; Endocrinology; Very low-density lipoprotein; Dyslipidemia; Apolipoprotein B; Biology; Sphingosine; Ceramide; Insulin; Cholesterol; Lipoprotein; Medicine; Diabetes mellitus; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003040695,0.0008064382,0.0008614866,0.001036733,0.0003526971,0.0005402325,0.0003928044,0.0006281009,0.00188296],"category_scores_gemma":[0.0002936154,0.0003251239,0.00039219,0.0004027226,0.0005828897,0.0004528018,0.0002925355,0.001564767,0.0003857956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004108689,"about_ca_system_score_gemma":0.0005390242,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001629974,"about_ca_topic_score_gemma":0.001849247,"domain_scores_codex":[0.9998201,0.00003520962,0.00002296883,0.00003246918,0.00003866113,0.00005062049],"domain_scores_gemma":[0.9994894,0.00004683917,0.0001003472,0.00008288768,0.00005100945,0.0002294538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006785437,0.001212439,0.0006933406,0.00007561739,0.00006361365,0.00007358989,0.00002772803,0.000155872,0.9850093,0.0001664107,0.0001547997,0.005581843],"study_design_scores_gemma":[0.000987974,0.007198008,0.009599435,0.0000252864,0.0001703767,0.000149977,0.00006804624,0.001570411,0.977665,0.0002845374,0.002259501,0.00002152783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963038,0.000967252,0.001013871,0.0002841617,0.00008111223,0.00002524138,0.0003051455,0.000188159,0.0008312136],"genre_scores_gemma":[0.9914854,0.001322135,0.001587732,0.0001773389,0.00004708986,0.00005065749,0.0006354313,0.00007656732,0.004617744],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00188296,"threshold_uncertainty_score":0.006299138,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04112965629593755,"score_gpt":0.2729761129325469,"score_spread":0.2318464566366094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}