{"id":"W2094523134","doi":"10.1007/s10549-014-3100-x","title":"Pathologic complete response to neoadjuvant cisplatin in BRCA1-positive breast cancer patients","year":2014,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":269,"is_retracted":false,"has_abstract":false,"ca_institutions":"Women's College Hospital; Sunnybrook Health Science Centre","funders":"","keywords":"Breast cancer; Medicine; Chemotherapy; Oncology; Internal medicine; Cisplatin; Cancer; Stage (stratigraphy); Mastectomy; Neoadjuvant therapy; BRCA mutation; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005830945,0.0002378362,0.000249319,0.0002148349,0.0001903227,0.00006733445,0.0001975316,0.0001138772,0.00008957121],"category_scores_gemma":[0.00006198276,0.0001925844,0.00005276789,0.0003464661,0.0001772202,0.000008702021,0.0002084497,0.0001315364,0.0000257299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007874256,"about_ca_system_score_gemma":0.0003618695,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002408371,"about_ca_topic_score_gemma":0.002950904,"domain_scores_codex":[0.9974715,0.000522574,0.0002586845,0.0007516324,0.0003951324,0.000600554],"domain_scores_gemma":[0.9987417,0.0001032799,0.00005831975,0.0004082029,0.0004179814,0.0002704866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.01698161,0.001327549,0.3963515,0.00002660071,0.0002600299,0.00006513079,0.001347064,0.0008800316,0.1080877,0.00007612394,0.003405663,0.471191],"study_design_scores_gemma":[0.003120963,0.001580808,0.9828293,0.00007254294,0.00001234853,0.00005146816,0.0001107499,0.00007231202,0.005727517,0.000113313,0.006067148,0.0002415821],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919122,0.0005390378,0.00004484024,0.004125319,0.000101147,0.0007128807,0.002332576,0.000008753728,0.0002232495],"genre_scores_gemma":[0.9972371,0.0004151726,0.0001584242,0.0002862883,0.0002138186,0.001033214,0.0001170877,0.000031638,0.0005072717],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5864777,"threshold_uncertainty_score":0.7853363,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02920730775215029,"score_gpt":0.3459699104367928,"score_spread":0.3167626026846425,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}